BRCA

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BRCA

Either of two tumor suppressor genes (BRCA1 or BRCA2) that are associated with an increased risk of developing familial breast and ovarian cancer when inherited in a mutated state.

[br(east) ca(ncer).]

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References in periodicals archive ?

First of all, the company clearly states on its website that it screens for only three of the more prevalent BRCA breast and ovarian cancer mutations, and emphasizes that there are hundreds of potentially carcinogenic mutations in the BRCA1 and BRCA2 genes for which it does not test.

Leave 23andMe alone: the FDA should stop obstructing consumer-driven genetic testing

So for years, doctors have advised BRCA carriers to have their ovaries removed between the ages of 35 and 40, or when women are finished having children.

Ovary removal aids high-risk women

'Women should have their family history assessed to help make sure that clinicians identify the small number of women with BRCA mutations," Dr.

USPSTF: Screen at-risk women for BRCA mutations

[12] We therefore describe a programme for genetic counselling and BRCA testing developed in a resource-constrained environment, how it evolved over time and the rates of BRCA mutation detection and family follow-up achieved.

Implementation of a breast cancer genetic service in South Africa--lessons learned

Patients with cancers linked to BRCA mutations saw the most substantial improvement.

Giving hope to victims of cancer gene; North scientists help create drug with impressive results

Dentro de este grupo de genes estan los denominados BRCA 1 y BRCA2 (por sus siglas en ingles breast related cancer allele 1 y 2), los cuales estan asociados a una mayor presentacion de cancer de mama y ovario y contribuyen al 90 % de los canceres de ovario hereditarios y por lo menos al 50 % de los mamarios correspondientes (7-10).

Cancer de mama asociado a mutaciones geneticas de los BRCA 1 y 2

Keywords: BRCA mutation, preimplantation genetic diagnosis, human reproduction, couples, genetic inheritance

"My funky genetics": BRCA1/2 mutation carriers' understanding of genetic inheritance and reproductive merger in the context of new reprogenetic technologies

"Breast cancer is very prevalent, but the BRCA founder mutations are rare, occurring in less than 1% of all women," explained task force member Dr.

U.S. Task Force Updates Breast Cancer Gene Testing Recommendations

HRR gene mutations occur in approximately 25% of men diagnosed with mCRPC within which BRCA 1/2 and ATM form the majority.

Lynparza Phase 3 PROfound Trial in HRR Mutation-Selected Metastatic Castration-Resistant Prostate Cancer Met Primary Endpoint

Inherited BRCA gene mutations are responsible for about one in five ovarian cancers.

Ovarian cancer 'game changing' drug which holds back disease's return gets NHS approval; Lymparza (olaparib) could even offer a cure for some women suffering from the notoriously deadly and difficult to treat cancer

Roy Baynes, Senior Vice President and Head of Global Clinical Development, Chief Medical Officer, MSD Research Laboratories, said: Advances in understanding the role of BRCA mutations and PARP inhibition have fundamentally changed how physicians can treat this aggressive type of cancer.

United Kingdom : Lynparza approved in Japan for 1st-line maintenance therapy in BRCA-mutated advanced ovarian cancer

Once fully recovered, and with no useful book available to help BRCA mutation carriers like myself, I dedicated my time to writing a book on the BRCA gene.