Infection with HPV is opportunistic, and the virus gains access to the basal cell layer
following micro-abrasions along the squamous epithelium.
It involves the prostatic gland globally and is characterized by prominence of the basal cell layer
and a decrease in cellular size and cytoplasm of the luminal cells.
This intraglandular proliferation is consistently surrounded by a basal cell layer
that is often attenuated and disrupted, especially in high-grade PIN.
The epidermis has four layers: the stratum corneum, the granular layer, the squamous cell layer and the basal cell layer
Genomics of Epidermolysis Bullosa EB Type Level of Blistering Genes Simplex Basal cell layer
KRT5, KRT14 Hemidesmosomal Basal cell/lamina BPAG2, ITGB4, ITGA6 lucida interface (PLEC1 with muscular dystrophy) Junctional Lamina lucida LAMA3, LAMB3, LAMC2 Dystrophic Sublamina densa COL7A1 Source: Dr.
The bullae of pemphigus vulgaris develop in the deeper portion of the epidermis, just above the basal cell layer
, while more superficial and flaccid subcorneal bullae are seen in pemphigus foliaceus.
The scientists, led by Gary Halliday from the University of Sydney, wrote in the journal Proceedings of the National Academy of Sciences, 'The predominance of UVA mutations in the basal cell layer
reinforces the pivotal role UVA may play in the malignant transformation of human skin.
This mixture of yeasts, hyphae, and matrix material is not seen when the organism is grown in liquid culture or on an agar surface, which suggests that morphogenesis is triggered when an organism contacts a surface and that the basal cell layer
may have an important role in anchoring the biofilm to the surface (2,3,5,8).