Some of the variable features that have been proposed as the most helpful in making a diagnosis of MF on multivariate analysis include strikingly irregular nuclear contours, (4) haloed lymphocytes, (7) cerebriform lymphocytes as large as a basal keratinocyte
nucleus (ie, 7-9 im), (17) and a linear arrangement of epidermal lymphocytes at the dermalepidermal junction.
Epithelial cell-to-cell adhesion above the basal keratinocyte
layer is secured by specific adhesion complexes known as desmosomes.
Treatment with hyaluronic acid elicited a cutaneous reepithelization, laminin being present in basal keratinocyte
cytoplasm and discontinuous in the basement membrane (Fig.
The changes, bearing the hallmark of UVA damage, were found in the deep basal keratinocyte
3 Different external agents, especially viruses, and internal agents, like stress, and the heat shock protein antigen expression, associated or not, can alter the basal keratinocytes
of the oral mucosa making them a target of the cell immune response CD8+ T lymphocytes.
This gene expresses itself in basal keratinocytes
, where it encodes a protein, called Kindlin 1.
In nonlesional basal keratinocytes
, there are few keratin filaments, and mitochondria are prominent," Dr.
Moreover in the light of histopathological revelation of dermal mucin deposition along with interface changes and necrotic basal keratinocytes
in the absence of serum positivity for ANA antibody and RF, true existence of this syndrome is still doubtful.
The dermis is divided into two layers plus the basement membrane, which separates the basal keratinocytes
from the dermis.