SS220 (1S, 2'S) 2-methylpiperidinyl-3-cyclohexene-1-carboxamide) and Bayrepel (picardin, 1-methyl-propyl 2-(2-hydroxyethryl)-1-piperidinecarboxylate) are considered such candidates.
The purpose of this study was to evaluate 2 formulations each of SS20 and Bayrepel against deet using volunteers acting as both treatment and their own control against Anopheles, Aedes, Coquillettidia, and especially Culex and Mansonia, the 2 most prevalent mosquito species in Kisumu, western Kenya.
The following 5 repellent formulations were used: (1 and 2) SS220 ((1S, 2'S) 2-methylpiperidinyl-3cyclohexene-1-carboxamide) formulated as a spray (20%) or a lotion (20%) by Avon (New York, NY); (3 and 4) 20% Bayrepel, (1-methyl propyl 2-(2-hydroxyethryl)-1-pi-peridinecarboxylate) formulated as a lotion by Avon or SC Johnson (Racine, Wisconsin); (5) 33% V,V diethyl-3-methylbenzamide (deet) formulated as a cream by 3M (St Paul, MN).
The goal of this study was to compare repellent activity of deet with potential candidate replacements SS220 and Bayrepel against mosquito species commonly found in Kisumu, Kenya.
Therefore, this trial did not distinguish whether SS220 and Bayrepel were less or more effective than deet.
In a trial in Australia, (6) deet and Bayrepel were relatively much less active against Anopheles spp, where both protected volunteers for only up to one hour after application.
Bayrepel is an active substance tailored to the olfactory system of insects and is the first compound to overcome the disadvantages of traditional repellants, according to executives at Bayer Chemicals.
Bayrepel was introduced as part of Bayer's Autan product range five years ago.