SS220 (1S, 2'S) 2-methylpiperidinyl-3-cyclohexene-1-carboxamide) and Bayrepel (picardin, 1-methyl-propyl 2-(2-hydroxyethryl)-1-piperidinecarboxylate) are considered such candidates.
The purpose of this study was to evaluate 2 formulations each of SS20 and Bayrepel against deet using volunteers acting as both treatment and their own control against Anopheles, Aedes, Coquillettidia, and especially Culex and Mansonia, the 2 most prevalent mosquito species in Kisumu, western Kenya.
The following 5 repellent formulations were used: (1 and 2) SS220 ((1S, 2'S) 2-methylpiperidinyl-3cyclohexene-1-carboxamide) formulated as a spray (20%) or a lotion (20%) by Avon (New York, NY); (3 and 4) 20% Bayrepel, (1-methyl propyl 2-(2-hydroxyethryl)-1-pi-peridinecarboxylate) formulated as a lotion by Avon or SC Johnson (Racine, Wisconsin); (5) 33% V,V diethyl-3-methylbenzamide (deet) formulated as a cream by 3M (St Paul, MN).
The goal of this study was to compare repellent activity of deet with potential candidate replacements SS220 and Bayrepel against mosquito species commonly found in Kisumu, Kenya.
Therefore, this trial did not distinguish whether SS220 and Bayrepel were less or more effective than deet.
Picaridin - also known as Bayrepel
(after Bayer AG, the company which developed it) - has been used in Europe since 1998.
Bayrepel is an active substance tailored to the olfactory system of insects and is the first compound to overcome the disadvantages of traditional repellants, according to executives at Bayer Chemicals.
Bayrepel was introduced as part of Bayer's Autan product range five years ago.
Autan contains a new ingredient Bayrepel
, which is one of the most effective repellents.
All Autan products contain Bayrepel
, a unique formulation designed to offer tough protection against biting insects, whilst being kind to the skin.
Autan manufacturers Bayer have developed a unique new formula, Bayrepel
, which research has shown to be more effective than DEET.
It's not available yet in the United States, but is sold in Europe in a product called Bayrepel
, which is on the World Health Organization's list of recommended repellents.