Bence-Jones protein


Also found in: Medical, Encyclopedia.

Bence-Jones protein

 (bĕns′jōnz′)
n.
A protein occurring in the serum and urine of patients with certain diseases, especially multiple myeloma.

[After Henry Bence-Jones (1813-1873), British physician.]
American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.
References in periodicals archive ?
The graph of urine Bence-Jones protein electrophoresis also showed that there was an M protein band on the ELP.
All the above set the diagnosis of mesentery plasmacytoma, which was finally classified as SEP of the mesentery, since bone marrow examination was normal with less than 5% of plasma cells and concentrated urine was negative of Bence-Jones protein, while no other site of disease was revealed on additional imaging investigations, and renal parameters and calcium levels were normal.
Bence-Jones protein analysis was negative and beta-2-microglobulin was significantly elevated, at 10.48 mg/l.
We detected monoclonal IgG-kappa protein, not Bence-Jones protein, by serum and urine immunoelectrophoretic study.
Urinary Bence-Jones protein was estimated in 28 out of 44 patients and of them 4 (14%) were positive.
* The absence of Bence-Jones protein on the urine protein electrophoresis.
The serum protein electrophoresis (agarose gel) showed the presence of a monoclonal band in between beta and gamma regions and urine protein electrophoresis showed presence of Bence-Jones protein. The immunofixation electrophoresis of the serum and urine reported as IgD-kappa paraproteinaemia (Figure 1).
In patients with suspected MM, monoclonal heavy or light chains, known as Bence-Jones protein, should be analyzed in concentrated urine using electrophoresis with immunofixation of any identified protein bands in accordance with current myelomas guidelines [27].
Their observations led to the discovery of the protein (known as Bence-Jones protein) found in urine of patients with multiple myeloma.