Summary: A series of novel benzamide
derivatives according to fluopicolide were designed and synthesized following the rule of combination carboxylic acid amides and amines derivatives together.
Ni (II) and Zn (II) complexes of 2-((thiophen-2-ylmethylene) amino) benzamide
: Synthesis, spectroscopic characterization, thermal, DFT and anticancer activities.
bifunctional molecule was found to be active for class I deacetylases (HDAC3) and class II deacetylases (HDAC6) and was potent in nM concentration in breast cancer models.
Initial experiments were performed using 3-nitrobenzaldehyde (1 mmol), benzamide
(2a, 1 mmol), and 2-naphthol (3, 1 mmol) as the model reaction.
Reglan[R], a substituted benzamide
, increases emptying of the stomach, thus decreasing the chance of developing nausea and vomiting due to food remaining in the stomach.
Chidamide (CS055/HBI-8000/Tucidinostat) is an orally bioavailable, low-nanomolar inhibitor of cancer-associated histone deacetylase (HDAC) enzymes with favorable pharmacology and tolerability profiles relative to existing benzamide
and non-benzamide HDAC inhibitors.
N-(4-Carbamoylphenyl)Furan-2-Carboxamide (CFC) was prepared by a procedure similar to that reported in the literature; 4-Amino benzamide
(3.00g, 0.0220 mol) and 2-furoyl chloride (3.428 g, 0.0264 mol) were dissolved in mixture of MDC (70 ml) and THF (25 ml).
The position of amide I, amide II, and III bands at 1656, 1537, and 1306 [cm.sup.-1], respectively, arising from the carbonyl of the benzamide
moiety and secondary amide of DEBT at 3276 [cm.sup.-1] disappeared in the complex.
TRIG is a new brand of mosquito repellent petroleum jelly, with 15% N-N DIETHYL Benzamide
, and was evaluated for its efficacy against man-biting mosquitoes.
Raeppel et al., "Discovery of N-(2-aminophenyl)-4-[(4-pyridin-3-ylpyrimidin-2-ylamino)methyl] benzamide
(MGCD0103), an orally active histone deacetylase inhibitor," Journal of Medicinal Chemistry, vol.
Cinitapride (Figure 1), chemically 4-amino-N-[3-(cyclohexan1-yl-methyl)-4-piperidinyl]-2-ethoxy-5-nitrobenzamide, is a substituted benzamide
gastroenteric prokinetic agent acting via complex, but synergistic effects on serotonergic 5-HT2 (inhibition) and 5-HT4 (stimulation) receptor and dopaminergic D2 (inhibition) receptors in the neuronal synapses of the myenteric plexi [1-3].