This research revealed that beta-cyclodextrins
, particularly the proprietary beta-cyclodextrin
Captisol, enabled a high concentration of furosemide at neutral pH.
Vine et al., "The antiangiogenic properties of sulfated beta-cyclodextrins in anticancer formulations incorporating 5-fluorouracil," Anticancer Drugs, vol.
Chollet et al., "Improvement in solubility and dissolution rate of 1, 2-dithiole-3-thiones upon complexation with beta-cyclodextrin and its hydroxypropyl and sulfobutyl ether-7 derivatives," Journal of Pharmaceutical Sciences, vol.
We also found that gamma-cyclodextrins were more successful than beta-cyclodextrins
and were more cost-effective," Schmidt said.
Based on previous literature findings that described collagen fibrils (5-7) and beta-cyclodextrins
(8-14), computer-assisted three-dimensional scale models of collagen segments and anticipated examples of beta-cyctodextrin's poiymerizabie derivatives were prepared and studied.
Now, Cerestar has announced that it will proceed with the commercial development of beta-cyclodextrins
. Cerestar, a company of Eridania Beghin-Say, Hammond, Ind., has participated in the approval process of beta-cyclodextrins
since 1996, and has recently received GRAS status.
Especially costly is gamma-cyclodextrin with a "donut hole" larger than those of alpha- and beta-cyclodextrins
. Its cavity is easily capable of binding cyclic molecules that have 12 or more atoms in their rings.
Spain has allowed beta-cyclodextrins
in food products since 1987.