beta-lactamase

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be·ta-lac·ta·mase

 (bā′tə-lăk′tə-mās′, -māz′, bē′-)
n.
Any of various enzymes that hydrolyze and inactivate beta-lactam antibiotics such as penicillin, found in many antibiotic-resistant bacteria.

[beta-lactam, cyclic amide occurring in penicillins (beta + lact(one) + am(ide)) + -ase.]
American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.beta-lactamase - enzyme produced by certain bacteria that inactivates penicillin and results in resistance to that antibiotic
enzyme - any of several complex proteins that are produced by cells and act as catalysts in specific biochemical reactions
Based on WordNet 3.0, Farlex clipart collection. © 2003-2012 Princeton University, Farlex Inc.
Translations

be·ta-lac·ta·mase

a. beta-lactamasa, enzima que destruye el conjunto de beta-lactam antibióticos penicílicos haciéndolos no efectivos;
beta-lactamase resistanceresistencia de beta-lactamasa, a algunos tipos de penicilina.
English-Spanish Medical Dictionary © Farlex 2012
References in periodicals archive ?
may be intrinsically resistant or have acquired resistance to antibiotics due to permeability barrier of the cell surface, multidrug efflux pumps and production of beta-lactamases (Amp-C and ESBL).
Detection of metallo beta-lactamases among Gram-negative bacterial isolates from Murtala Muhammad Specialist Hospital, Kano and Almadina Hospital Kaduna, Nigeria.
Molecular characterization of addiction systems of plasmids encoding extended-spectrum beta-lactamases in Escherichia coli.
The Bush-Medeiros-Jacoby classification system groups are classified on the basis of their functional characteristics.4,5 ESBLs are beta-lactamases belonging to group 2be in the Bush-Jacoby-Medeiros system and to class A in the Ambler system.
Following emergence of KPC beta-lactamases in 2013, the first outbreak associated with KPC-2 was observed at Sestre milosrdnice University Hospital Center in 2014 (7).
The first description of extended spectrum beta-lactamases (ESBLs) in 1983, production of beta-lactamase is one of the strategies adopted by bacteria to develop resistance to beta-lactam class of antibiotics.
Jacoby, "Updated functional classification of beta-lactamases," Antimicrobial Agents and Chemotherapy, vol.
Beta-lactamases are enzymes (EC 3.5.2.6) produced by some bacteria and are responsible for their resistance to beta-lactam antibiotics like penicillins, cephalosporins (are relatively resistant to beta-lactamase), cephamycins, and carbapenems (ertapenem).
Diversity of extended-spectrum beta-lactamases and class C beta-lactamases among cloacal Escherichia coli isolates in Belgian broiler farms.
Diversity of beta-lactamases produced by ceftazidime-resistant Pseudomonas aeruginosa isolates causing bloodstream infections in Brazil.
Lack of beta-lactamases in Pseudomonas aeruginosa of animal origin and water
Occurrence and detection of AmpC beta-lactamases among Escherichia coli, Klebsiella pneumoniae and Proteus mirabilis isolates at a veterans medical center.

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