sequestrant

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se·ques·trant

 (sĭ-kwĕs′trənt)
n.
A chemical that promotes sequestration.
American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.

sequestrant

(sɪˈkwɛstrənt)
n
(Horticulture) chem any substance used to bring about sequestration, often by chelation. They are used in horticulture to counteract lime in the soil
Collins English Dictionary – Complete and Unabridged, 12th Edition 2014 © HarperCollins Publishers 1991, 1994, 1998, 2000, 2003, 2006, 2007, 2009, 2011, 2014
References in periodicals archive ?
Ironwood is also advancing two late-stage GI product candidates: IW-3718 is a gastric retentive formulation of a bile acid sequestrant being developed for the potential treatment of persistent gastroesophageal reflux disease, and MD-7246 is a delayed-release formulation of linaclotide that is being evaluated as an oral, intestinal, non-opioid, pain-relieving agent for patients suffering from abdominal pain associated certain GI diseases.
We are also advancing two late-stage GI product candidates: IW-3718 is a gastric retentive formulation of a bile acid sequestrant being developed for the potential treatment of persistent gastroesophageal reflux disease, and MD-7246 is a delayed-release formulation of linaclotide that is being evaluated as an oral, intestinal, non-opioid, pain-relieving agent for patients suffering from abdominal pain associated certain GI diseases.
Because a subset (approximately 28%) of patients with IBS-D have bile acid malabsorption, an empiric trial of a bile acid sequestrant could be considered for diarrheal symptoms based on evidence of efficacy in recent pilot studies (eg, cholestyramine, 9 g two to three times daily, colestipol, 2 g once or twice daily, or colesevelam, 625 mg once or twice daily).
Clinically, BAM is classified as follows [3]: type 1: ileal dysfunction/resection (Crohn's disease); type 2: primary or idiopathic, characterised by watery diarrhea with (IBS) or without (FD) pain responding to bile acid sequestrant drugs (BASs); type 3: associated with other gastrointestinal disorders such as coeliac disease, small intestinal bacterial overgrowth (SIBO), and chronic pancreatitis; and type 4: due to an impaired FGF-19 feedback inhibition that causes excessive BA synthesis [4].
Fish scales can be seen in histologically processed gallbladder calculi (A), dystrophic calcifications (B), unspecified luminal material (favor food; C), and occasionally in large bile acid sequestrant fragments (see Figures 4, C and F, and 5), suggesting that fish scales are a histologic artifact of knife-cutting.
Historically this condition was treated with cholestyramine powders; although now almost redundant in this area of treatment this bile acid sequestrant was effective in converting cholesterol into bile acids, which were excreted from the body effectively.
Other agents such as phenobarbital and the bile acid sequestrant, cholestyramine, have been studied in a small randomised trial in France, with no significant benefit.
Since 2000 Welchol, a bile acid sequestrant, has been indicated--alone or in combination with a statin--for the reduction of elevated LDL-C levels in patients with primary hypercholesterolemia.
Bile acid sequestrant Decreases cholesterol by preventing reabsorption of cholesterol.
Colesevelam (Welchol), a bile acid sequestrant, is the only agent approved by the Food and Drug Administration for both treatment of dyslipidemia and improving glycemic control in type 2 diabetes.
Many combination drug therapies are effective in treating dyslipidemia, Compared with statin monotherapy, combinations that include ezetimibe (Zetia), a bile acid sequestrant, or niacin further lower low-density lipoprotein (LDL) cholesterol (strength of recommendation [SOR]: A), and increase the likelihood of attaining National Cholesterol Education Program (NCEP) LDL cholesterol goals (SOR: B).
The bile acid sequestrant drugs are often prescribed as an adjunct to statin therapy (Illingworth, 2001).