Intra-Cellular Therapies announced top-line results from two Phase 3 clinical trials evaluating lumateperone as monotherapy in the treatment of major depressive episodes associated with Bipolar I or Bipolar II disorder
. In Study 404, lumateperone 42 mg met the primary endpoint for improvement in depression as measured by change from baseline versus placebo on the MADRS total score.
If one were looking for a simple throughline of Heart Berries, you might say it is the memoir of a woman diagnosed with post-traumatic stress disorder and bipolar II disorder
. You might say that it traces how her childhood led to these diagnoses and that it follows the impact they have on her current family.
We also argued that subthreshold hypomania is the rule and not the exception in bipolar II disorder
, that antidepressant monotherapy rarely causes manic switches but is more likely to worsen depression, and that although antidepressant monotherapy usually destabilizes bipolar illness, antidepressants can be helpful when combined with mood stabilizers.
Based on his MDQ results, the clinical interview, and current episode with mixed features, the patient was given a diagnosis of bipolar II disorder
. The psychiatrist prescribed divalproex 500 mg at bedtime and scheduled a return visit with a plan for further laboratory monitoring and up-titration if needed.
The star revealed she is in therapy and taking medication for bipolar II disorder
She was diagnosed with bipolar II disorder
in 2001, after her infamous 'emotional and physical breakdown' that landed her then in psychiatric care.
The singer-songwriter is now in therapy and taking medication for bipolar II disorder
, which involves periods of depression as well as hypomania, reports the magazine.
Mariah told People magazine: "I'm comfortable discussing my struggles with bipolar II disorder
Carey told People that it was during a hospitalization in 2001 that she was diagnosed with bipolar II disorder
-- which, she said, she "didn't want to believe."
"I'm just in a really good place right now, where I'm comfortable discussing my struggles with bipolar II disorder
. I'm hopeful we can get to a place where the stigma is lifted from people going through anything alone," she said.
 Because of psychotic symptoms, 31% of patients with bipolar I disorder were mistakenly diagnosed as having other disorders with obvious psychotic symptoms such as schizophrenia or substance use induced psychotic disorders. The reason for this may be related to clinical practitioners who believe that Schneider's first rank symptoms are specific symptoms of schizophrenia. Patients with bipolar II disorder
were usually misdiagnosed as having unipolar depression. The reason might be related to the disease characteristics of bipolar disorder.
Rihmer Z, Pestality P (1999) Bipolar II disorder
and suicidal behavior.