crisis

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Related to Blast crisis: AML

cri·sis

 (krī′sĭs)
n. pl. cri·ses (-sēz)
1. A crucial or decisive point or situation, especially a difficult or unstable situation involving an impending change.
2. A sudden change in the course of a disease or fever, toward either improvement or deterioration.
3. An emotionally stressful event or traumatic change in a person's life.
4. A point in a story or drama when a conflict reaches its highest tension and must be resolved.

[Middle English, from Latin, judgment, from Greek krisis, from krīnein, to separate, judge; see krei- in Indo-European roots.]

crisis

(ˈkraɪsɪs)
n, pl -ses (-siːz)
1. a crucial stage or turning point in the course of something, esp in a sequence of events or a disease
2. an unstable period, esp one of extreme trouble or danger in politics, economics, etc
3. (Pathology) pathol a sudden change, for better or worse, in the course of a disease. Also (archaic): crise
[C15: from Latin: decision, from Greek krisis, from krinein to decide]

cri•sis

(ˈkraɪ sɪs)

n., pl. -ses (-sēz).
1. a turning point, as in a sequence of events, for better or for worse.
2. a condition of instability, as in international relations, that leads to a decisive change.
3. a personal tragedy, emotional upheaval, or the like.
4.
a. the point in the course of a serious disease at which a decisive change occurs, leading to recovery or to death.
b. the change itself.
5. the point, as in a play, at which the antagonistic elements confront each other.
[1375–1425; late Middle English < Latin < Greek krísis decision =kri- variant s. of krinein to decide, separate + -sis -sis]

crisis

An incident or situation involving a threat to the United States, its territories, citizens, military forces, possessions, or vital interests that develops rapidly and creates a condition of such diplomatic, economic, political, or military importance that commitment of US military forces and resources is contemplated in order to achieve national objectives.
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.crisis - an unstable situation of extreme danger or difficultycrisis - an unstable situation of extreme danger or difficulty; "they went bankrupt during the economic crisis"
Dunkirk - a crisis in which a desperate effort is the only alternative to defeat; "the Russians had to pull off a Dunkirk to get out of there"
exigency - a pressing or urgent situation; "the health-care exigency"
critical point, crossroads, juncture - a crisis situation or point in time when a critical decision must be made; "at that juncture he had no idea what to do"; "he must be made to realize that the company stands at a critical point"
situation - a complex or critical or unusual difficulty; "the dangerous situation developed suddenly"; "that's quite a situation"; "no human situation is simple"
economic crisis, slump, depression - a long-term economic state characterized by unemployment and low prices and low levels of trade and investment
2.crisis - a crucial stage or turning point in the course of something; "after the crisis the patient either dies or gets better"
juncture, occasion - an event that occurs at a critical time; "at such junctures he always had an impulse to leave"; "it was needed only on special occasions"
emergency, exigency, pinch - a sudden unforeseen crisis (usually involving danger) that requires immediate action; "he never knew what to do in an emergency"

crisis

noun
2. critical point, climax, point of no return, height, confrontation, crunch (informal), turning point, culmination, crux, moment of truth, climacteric The anxiety that had been building within him reached a crisis.

crisis

noun
1. A decisive point:
2. A highly volatile dangerous situation requiring immediate remedial action:
Translations
أَزْمَةأزْمـهضائِقَـه، وَقت الأزمَـه
krizekritická situace
krisekrisetilstandvendepunkt
kriisi
kriza
krízisválság
hættuástandkreppaumhvörf; hættuástand; krísa
クライシス危機重大局面
위기
krizėpavojussukrėtimas
kritiska situācijakrīze
kriza
kris
ช่วงวิกฤต
cuộc khủng hoảng

crisis

[ˈkraɪsɪs]
A. N (crises (pl)) [ˈkraɪsiːz]crisis f inv (Med) → punto m crítico
to come to a crisisentrar en crisis
we've got a crisis on our handsestamos enfrentándonos a una crisis
B. CPD crisis centre (Brit) crisis center (US) N (for disaster) → centro m coordinador de rescate; (for personal help) → teléfono m de la esperanza; (for battered women) → centro m de ayuda (a las mujeres maltratadas)
crisis management Ngestión f de crisis

crisis

[ˈkraɪsɪs] [crises] [ˈkraɪsiːz] (pl) ncrise f
economic crisis → crise f économique
financial crisis → crise f financière
hostage crisis → crise f des otages
refugee crisis → crise f des réfugiés
budget crisis → crise f budgétaire
energy crisis → crise f de l'énergie
to be in crisis → être en crise
in times of crisis → en temps de crise crisis management, crisis of confidence, identity crisis, Gulf Crisiscrisis management ngestion f de crisecrisis of confidence ncrise f de confiance

crisis

n pl <crises> → Krise f (also Med); to reach crisis pointden Höhepunkt erreichen; that was a crisis in his life (= decisive moment)das war ein entscheidender Punkt in seinem Leben; (= emotional crisis)das war eine Krise in seinem Leben; at this time of crisisin dieser krisenreichen or schweren Zeit; in times of crisisin Krisenzeiten

crisis

:
crisis centre
nEinsatzzentrum nt (für Krisenfälle); rape crisisBeratungsstelle f (für Frauen, die Opfer einer Vergewaltigung geworden sind)
crisis management

crisis

[ˈkraɪsɪs] n (crises (pl)) [ˈkraɪsiːz]crisi f inv
to come to a crisis → entrare in crisi
we have a crisis on our hands → ci troviamo di fronte a una crisi

crisis

(ˈkraisis) plural ˈcrises (-siːz) noun
1. a deciding moment or turning-point (especially of an illness). Although she is still very ill, she has passed the crisis.
2. a time of great danger or difficulty. a crisis such as the recent flooding; You can rely on her in a crisis.

crisis

أَزْمَة krize krise Krise κρίση crisis kriisi crise kriza crisi 重大局面 위기 crisis krise kryzys crise кризис kris ช่วงวิกฤต kriz cuộc khủng hoảng 危机

crisis

n (pl -ses) crisis f; blast — crisis blástica; identity — crisis de identidad; midlife — crisis de la mediana edad
References in periodicals archive ?
The company said Imatinib mesylate tablets are indicated for newly diagnosed adult and pediatric patients with Philadelphia chromosome positive chronic myeloid leukemia (Ph+ CML) in chronic phase as well as in patients with Ph+ CML in blast crisis, accelerated phase, or in chronic phase after failure of interferon-alpha therapy.
Further, this study also demonstrated that the combination of pacritinib at low nanomolar concentrations with dasatinib may eliminate self-renewing leukemia stem cells in blast crisis of chronic myeloid leukemia (CML) with minimal toxicity toward normal progenitors.
Although, with CML, blast crisis can occur, making it behave much more like an acute leukemia.
The Bone marrow pictures in CML without treatment showing hypercellularity due to excessive proliferation of the granulocytes with myelocytes predominantly and presence of blast cells from <10% to >20% in the bone marrow and peripheral blood according to the world health organization criteria that divide the CML in to chronic, accelerated phases and blast crisis, there is decreased or normal or increased megekayrioposis as well as moderate to marked reticulin fibrosis with presence of small megakaryocyte containing hypolobulated nuclei, sea-blue histiocytes and gaucher cell and these changes are return to the normal state after treatment and the immunohisto-chemistry is used for differentiating the myeloblastic and lymphoblastic crisis of CML [7,8].
The manifestations of blast crisis are similar to acute leukemia.
There have been a few case reports published of Philadelphia chromosome-positive acute myeloid leukemia (Ph+ AML) presenting as megakaryoblastic blast crisis.
The blast crisis is the final phase of CML when overabundant, abnormal white blood cells crowd out healthy cells, causing serious dysfunction.
As CML evolves and the blast count rises, the disease can enter an aggressive or accelerated phase and can terminate in an acute phase or blast crisis when the blast count is greater than 20%.
Washington, March 5 (ANI): Scientists in the US have discovered why a form of leukemia progresses from its more-treatable chronic phase to a life-threatening phase called blast crisis.
Patients in blast crisis develop complications such as bleeding or sepsis, eventually leading the patient to succumb to the systemic disease.
Imatinib mesylate, an inhibitor of Bcr-Abl tyrosine kinases, has revolutionized the treatment of chronic myelogenous leukemia (CML), showing marked improvements in survival in all three phases of the disease: chronic, accelerated, and blast crisis (see Figure 1).