"A disease caused by the inhalation of mold conidia (spores) of Blastomyces dermatitidis
, which convert to yeasts and invade the lungs, occasionally spreading hematogenously to the skin or focal sites in other tissues...
is a dimorphic fungus that may cause a systemic pyogranulomatous inflammation following inhalation of conidia in both immunocompetent and immunocompromised patients.
Blastomycosis is a pyogranulomatous infection caused by a dimorphic fungus, Blastomyces dermatitidis
. (1) Inhaled conidia of the Blastomyces leads to a primary lung infection.
These findings allowed the differentiation of other yeast fungi such as Histoplasma capsulatum and Blastomyces dermatitidis
, as well as parasitic infections by Mullerius capillaris and Dictyocaulus filaria (CASWELL & WILLIAMS, 2016).
It is often the first choice for the treatment of infections caused by Blastomyces dermatitidis
, Histoplasma capsulatum, and Aspergillus spp., and to treat onychomycosis (36).
* Red Fox as a Sentinel for Blastomyces dermatitidis
, Ontario, Canada
Otras micosis endemicas prevalentes incluyen las enfermedades producidas por Blastomyces dermatitidis
, Coccidioides immitis, Paracoccidioides braziliensis y Penicillium marneffei.
There is cross-reactivity of the Histoplasma antigen test with antigens from other endemic mycoses including Blastomyces dermatitidis
, Paracoccidioides brasiliensis, Coccidioides immitis, and Coccidioides posadasii .
Basic Local Alignment Search Tool (BLAST) revealed 93% identity with Hsp60 from Blastomyces dermatitidis
and Histoplasma capsulatum, and 89 and 81% with Hsp60 from Aspergillus fumigatus and Sporothrix schenckii, respectively (data not shown).
(2) Although these methods have the advantage of being non-invasive, but enclose several limitations, including (i) marked intra-patients variation in results; (ii) long time for positive results (up to six weeks are required after exposure for antibody production); (iii) potential cross-reactivity with antibodies produced by other fungi such as Blastomyces dermatitidis
Smith, "Cutaneous lesions showing giant yeast forms of Blastomyces dermatitidis
," Journal of Cutaneous Pathology, vol.
to efficiently evade/manipulate the host immune response, occasionally based on studies performed in other endemic dimorphic fungi (Blastomyces dermatitidis
, Histoplasma capsulatum), where there is deeper understanding of the molecular mechanisms associated with key microbial components.