blood-brain barrier

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blood-brain barrier

(blŭd′brān′)
n.
A physiological mechanism that alters the permeability of brain capillaries, so that some substances, such as certain drugs, are prevented from entering brain tissue, while other substances are allowed to enter freely.

blood′-brain′ bar`rier


n.
a layer of tightly packed cells that make up the walls of brain capillaries and prevent many substances in the blood from diffusing into the brain.
[1940–45]
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.blood-brain barrier - a mechanism that creates a barrier between brain tissues and circulating blood; serves to protect the central nervous system; "the brain was protected from the large molecules of the virus by the blood-brain barrier"
barrier - anything serving to maintain separation by obstructing vision or access
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References in periodicals archive ?
s (TSX: PMN) lead product candidate for Alzheimer's disease, PMN310, showed similar ability to cross the blood brain barrier and penetrate the central nervous system compared to aducanumab (Biogen), the company said.
The company said the blood brain barrier restricts the passage of substances from the bloodstream into the brain, protecting it from toxins.
In these mice, the cells that form the blood brain barrier have broken down and become "leaky" - a likely combination of aging and the cumulative effect of toxic assaults - allowing elements such as copper to pass unimpeded into the brain tissue.
However, they are ineffective because the blood brain barrier stops them from reaching their destination directly.
After 12 weeks of a high-cholesterol diet, the blood brain barrier in those given caffeine was far more intact than in those given no caffeine.
Researcher Jonathan Geiger said: "For the first time, we have shown chronic ingestion of caffeine protects the blood brain barrier from cholesterol-induced leakage.
However, curcumin cannot pass the blood brain barrier which protects the brain from potentially toxic molecules.