blood-brain barrier


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blood-brain barrier

(blŭd′brān′)
n.
A physiological mechanism that alters the permeability of brain capillaries, so that some substances, such as certain drugs, are prevented from entering brain tissue, while other substances are allowed to enter freely.

blood′-brain′ bar`rier


n.
a layer of tightly packed cells that make up the walls of brain capillaries and prevent many substances in the blood from diffusing into the brain.
[1940–45]
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.blood-brain barrier - a mechanism that creates a barrier between brain tissues and circulating blood; serves to protect the central nervous system; "the brain was protected from the large molecules of the virus by the blood-brain barrier"
barrier - anything serving to maintain separation by obstructing vision or access
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References in periodicals archive ?
To accomplish this, Cho and his research teamworking in partnership with Old Dominion University and Purdue Universityhave created tissue-based models mirroring the properties of tissue and fluids found in the brain and blood-brain barrier.
Blood-Brain Barrier in Drug Discovery: Optimizing Brain Exposure of CNS Drugs and Minimizing Brain Side Effects for Peripheral Drugs
This blood-brain barrier breaks down with age, possibly playing a role in Alzheimer's disease, a new study suggests.
When the researchers later examined all of the rats' blood-brain barriers, they found that the obese rats' blood-brain barriers had become impaired as they allowed a much larger amount of a dye that does not freely cross the blood-brain barrier into the hippocampus than did blood-brain barriers of the non-obese rats.
Summary: TEHRAN (FNA)- The blood-brain barrier is essential for maintaining the brain's stable environment -- preventing entry of harmful viruses and bacteria and isolating the brain's specific hormonal and neurotransmitter activity from that in the rest of the body.
My wife was told that one of the medicines she takes for her Parkinson's disease does not cross the blood-brain barrier, and yet may help her symptoms.
SEATTLE -- Angiotensin-converting enzyme inhibitors that cross the blood-brain barrier slow mental decline by about 50% relative to the decline seen in patients on other antihypertensives, according to an observational study of 1,074 hypertensive patients followed for a median of 6 years.
Blood-Brain Barrier (BBB) research embodies the true meaning of a "translational model" of neuroscience wherein breakthroughs in basic neuroscience are delivered to the clinic and require an agent delivery strategy and/or the ability to target specific areas of the brain.
But in MS, T cells activated for a myelin attack are able to wiggle through this blood-brain barrier.
Gliomas and other brain tumors are challenging to treat due to the presence of the blood-brain barrier.
In his latest research, Hobman has discovered how the virus breaks through the normally rock-solid blood-brain barrier to the central nervous system.
Infusions of manufactured alpha-L-iduronidase can ameliorate some symptoms but probably don't penetrate the blood-brain barrier and therefore don't prevent brain damage, says study coauthor Joanne Kurtzberg, a pediatric oncologist at Duke University Medical Center in Durham, N.