aprotinin

(redirected from Bovine pancreatic trypsin inhibitor)
Also found in: Medical, Acronyms.
Related to Bovine pancreatic trypsin inhibitor: Leupeptin, Pancreatic Secretory Trypsin Inhibitor

a·pro·ti·nin

 (ā-prōt′n-ĭn, ă-prōt′-)
n.
A polypeptide obtained from bovine lungs that is a protease inhibitor and has been used to reduce bleeding in patients undergoing cardiopulmonary bypass surgery. It was largely withdrawn from the market in 2007 because of safety concerns.

[a- + prot(e)in(ase) + -in.]
References in periodicals archive ?
PDB Source Inhibitor CODE 1AQ7 Bos taurus Aeruginosin 98-B 1AZ8 Bos taurus BIS-Phenylamidine Inhibitor 1EJM Bos taurus BPI Aprotinin 1JRS Bos taurus Leupeptin 1MTW Bos taurus DX9:(+)-2-[4-[((s)-1-acetimidoyl-3-pyrrodinyl) oxy]-3-7-amidino-2-napthyl) propionic acid 1QL8 Bos taurus ZEN: [4-(6-Chloro-Naphthalene-2-sulfonyl)- 1TPP Bos taurus APPA: (p-amidino-phenyl-pyruvate 1TPA Bos taurus BPTI: Bovine Pancreatic Trypsin Inhibitor 1TYN Bos taurus CTA:[cyclotheonamide A ] 1XUF Bos taurus BAZ:BIS(5-amidino-benzimidazolyl)methane zinc 3PTB Bos taurus Benzamidine Table III: Interactions in S1 and S2 specificity sites of thrombin in experimental structures of complexes with inhibitors.
Another ongoing structure determination at this time was of a new crystal form, form III, of bovine pancreatic trypsin inhibitor (26).
Sjolin, Structure of Bovine Pancreatic Trypsin Inhibitor.
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