Of note, the multinucleated giant cells of measles must be differentiated from other viruses (such as respiratory syncytial virus, which contains multinucleated cells with basophilic cytoplasmic inclusions, and other herpesviruses), giant cells due to pneumoconiosis, and nonspecific multinucleated reactive bronchial cells
, and multinucleated giant cells of granulomatous diseases.
Diego Baderna, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, focused on air quality, presenting the strategy adopted by the LIFE+ COBRA project to investigate the toxicity of brake-derived particulate matter on in vitro human bronchial cells
and ecological plant targets.
Dominic Keating, M.D., from Alfred Hospital in Melbourne, Australia, and colleagues examined the effects of VX-445-tezacaftor-ivacaftor on Phe508del CFTR protein processing, trafficking, and chloride transport in human bronchial cells
. A phase 2 trial was conducted in patients with Phe508del-MF and Phe508del-Phe508del.
According to general understanding, bronchial cells
are the same epithelial source as NSCLC cells, therefore they seems to be a good model to study all aspects of lung epithelial function and disease.
They found that the spice chemical cinnamaldehyde impaired the movement of tiny hair-like cilia that project from bronchial cells
Underscoring the relevance to humans, the researchers studied nasal and bronchial cells
from people who suffer from asthma or chronic rhinosinusitis (nasal congestion/sniffles) due to dust-mite sensitivity and found that on average these cells had a markedly lower expression of the dectin-1 gene.
Following adherence on the surface of bronchial cells
Moreover, knocking down of GBA2 reduced the intrinsic proinflammatory state of CF epithelial bronchial cells
Primary human bronchial cells
from asthmatic patients would have provided further insight to the beneficial effect of mannan in asthma; however, they are extremely difficult to acquire.
The researchers studied bronchial cells
exposed to aerosol from variable-voltage e-cigarettes.
Papanicolaou stained filters from all samples showed many cohesive three dimensional clusters of uniform cells with balling effects and smooth border (Figures 1a and 1b), cystic spaces, cribriform clusters, branching cylinders and solid clusters with ciliated bronchial cells
in the background.
Pathologic examination of a bronchoalveolar lavage (BAL) sample showed scattered cells, primarily columnar bronchial cells
, with cytomorphologic changes reminiscent of BK polyomavirus (BKPyV) infected decoy cells.