Los niveles de la proteina Mad, que son opuestos a los de c-Myc
, aumentan durante la diferenciacion celular, mientras que una baja expresion de la proteina Mad2 (Mxi-1) se asocia con el desarrollo de tumores en modelos murinos.
Detection of gene amplification in MYCN, C-MYC
, MYCL1, ERBB2, EGFR, AKT2, and human papilloma virus in samples from cervical smear normal cytology, intraepithelial cervical neoplasia (CIN I, II, III), and cervical cancer
This protein, called c-MYC
oncoprotein, can initiate and promote almost all human cancers and discovering the role it plays in cancer treatment resistance may lead to advances that save lives.
In a study published in Cell Death & Differentiation, researchers showed that THAP11 is frequently downregulated in several human tumor tissues and is able to suppress transcription of c-Myc
is known to regulate hTERT, expression of C-myc
was also determined.
The other topics are polyunsaturated fatty acid deficiency, the correlation between vascular endothelial growth factor and proto-oncogene c-fos and c-myc
, and the expression of neural cell adhesion molecules and osteonectin.
Furthermore, it was shown that the target RNA, from the c-myc
gene, one of the main causes of restenosis, was effectively inhibited by the antisense compound AVI-5126 developed by Cook Medical's partner AVI BioPharma, Inc.
Common to all Burkitt lymphomas, endemic or sporadic, are distinctive chromosomal translocations that reactivate expression of the c-myc
protooncogene and comprise the primary oncogenic mechanism.
is believed to regulate the many downstream genes that produce the pathology of restenosis, including cell migration and adhesion, collagen formation, secretion of extra-cellular matrix, and cell proliferation.
However, all the mice with the extra c-myc
and microRNA, developed lymphoma within about 50 days and died 2 weeks later, Hammond's team reports.
The hypothesis addressed in this research states that there is a unique set of genes related to the c-myc
basic/Helix/Loop/Helix, MyoD1, involved in the repair process of skeletal muscle atrophy.
The University of Warwick experts behind the five year research have compared the role of the protein, c-Myc
, to that of Bin Laden in international terrorism.