However, when URI is not present in these stem cells, the well-known oncogene c-MYC
is overexpressed, which leads to cell proliferation and increases susceptibility of these cells to radiation damage.
The presence of tetrasomy was confirmed with C-MYC
(8q24) and chromosome 8 centromeric probe cocktail.
The proteins activate c-Myc
(a well-known cancer gene), and its regulatory network.
(1) This form commonly results from a chromosome 8 translocation, involving the c-MYC
The relative mRNA expression levels of genes (DKK-1, beta-catenin, c-myc
, cyclin D1, and survivin) were normalized to GAPDH, calculated by using the [2.sup.-[DELTA][DELTA]Ct] method.
In fact, they can be phenotypically and genotypically different from surrounding tissue, including characteristic over-expression of c-Myc
and beta catenin.
RNA(1 [micro]g) was reverse transcribed using a QuantiTect cDNA kit and the PCR reactions were performed using the TaqMan Gene Expression Assays (Applied Biosystems) c-MYC
(Hs00811069_g1), S100A8 (Hs00374264_g1), S100A9 (Hs00374264_g1), and GAPDH (Primer design) using standard TaqMan reagents and protocols on a MX3500 (Stratagene) qRT-PCR machine.
Researchers have revealed genetic characteristics of PDAC [2, 3] and c-Myc
, an important transcription factor that is involved in various cellular processes including cell proliferation, differentiation, and apoptosis and acts as an oncogene in PDAC .
amplification in mucinous gastric carcinoma: A possible genetic alteration leading to deeply invasive tumors," AnticancerReseach, vol.
Another key defining feature of all three BL variants is a chromosomal translocation which juxtaposes the c-MYC
oncogene on chromosome 8 and one of the three Ig loci, most frequently the Ig heavy chain locus on chromosome 14 .