CD4


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CD4

 (sē′dē-fôr′)
n.
A glycoprotein that is found on the surface of T cells, especially helper T cells, and functions as a receptor in activation of the cells. In humans, HIV gains entry to helper T cells by binding to the CD4 receptor.

[c(luster of) d(ifferentiation antigen) 4.]
American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.

CD4


n.
a protein on the surface of T cells and other cells, functioning as a receptor for the AIDS virus antigen.
[1980–85; c(luster of) d(ifferentiation) 4]
Random House Kernerman Webster's College Dictionary, © 2010 K Dictionaries Ltd. Copyright 2005, 1997, 1991 by Random House, Inc. All rights reserved.
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.CD4 - a glycoprotein that is found primarily on the surface of helper T cells; "CD4 is a receptor for HIV in humans"
glycoprotein - a conjugated protein having a carbohydrate component
Based on WordNet 3.0, Farlex clipart collection. © 2003-2012 Princeton University, Farlex Inc.
References in periodicals archive ?
Co-trimoxazole (CTX) prophylaxis is recommended for adults (including pregnant women) with severe or advanced HIV clinical disease (WHO stage 3 or 4) and/or with a CD4 count <350 cells/[micro]l.
Altering CD4 gene methylation status, the expression was changed which related to resistance to virus infection [18] and inflammatory diseases [19].
Studies of nonlung cancers in people with HIV suggest that prolonged periods at a low CD4 count heighten cancer risk.
This implies that the association between the CD4 cell count and hypertension could be different across the various BMI categories.
Expression profiling of PD-1, CK7, CK20, Ki-67, E-Cad, and CD4 was assessed by IHC on 4 [micro]m thick FFPE sections.
Widespread and routine use of CD4 counts and plasma viral load in the management of HIV has not been possible in resource limited settings.
Median CD4 count and viral load collected closest to NTM diagnosis were 10 cells/[mm.sup.3] and 131,446 copies/mL, respectively.
The study secondarily purposed to observe a relationship between the classical CD4 and CD8 counts with each T cell subset's frequency.
In recent times one of the greatest challenges in the management and care of HIV in poor resource settings has been the evaluation of CD4 count measurement; a parameter which is seen as a traditional biomarker for predicting the progression and monitoring treatment response to highly active antiretroviral therapy (HAART) [7].
Lo descrito favorece la caracteristica fenotipica de esta entidad, caracterizada por un leve descenso de linfocitos T CD8+, por la disminucion de la relacion CD4:CD8 y porque los linfocitos B pueden estar disminuidos en algunos pacientes; sin embargo, en todos se encuentran concentraciones normales de inmunoglobulinas [2].