CD4 T cell


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Noun1.CD4 T cell - T cell with CD4 receptor that recognizes antigens on the surface of a virus-infected cell and secretes lymphokines that stimulate B cells and killer T cells; helper T cells are infected and killed by the AIDS virus
T cell, T lymphocyte - a small lymphocyte developed in the thymus; it orchestrates the immune system's response to infected or malignant cells
References in periodicals archive ?
Incomplete CD4 T cell recovery in HIV-1 infection after 12 months of highly active antiretroviral therapy is associated with ongoing increased CD4 T cell activation and turnover.
CD4 T cell help is limiting and selective during the primary B cell response to influenza virus infection.
Radbruch et al., "Differential immune cell dynamics in the CNS cause CD4 T cell compartmentalization," Brain, vol.
Dasegowda, "Comparing absolute lymphocyte count to total lymphocyte count, as a CD4 T cell surrogate, to initiate antiretroviral therapy," Journal of Global Infectious Diseases, vol.
In this study, we took advantage of the fact that the CD4 promoter is activated at the CD4/CD8 double positive stage of T cell development, and by mating the CD4-Cre and [STAT3.sup.f/f] mouse strains, we generated mice with deletion of STAT3 in CD8, as well as, the CD4 T cell compartment.
Comparison of mean CD4+ T cell counts between Ethiopian and Dutch populations showed considerably lower CD4 T cell counts in Ethiopian population (mean=775 cells/[micro]l) as compared to Dutch populations (mean= 993 cells/[micro]l) (58).
Characteristics, determinants, and clinical relevance of CD4 T cell recovery to <500 cellsl/[micro]L in HIV type 1-infected individuals receiving potent antiretroviral therapy.
The CD4 T cell count in peripheral blood is an important prognostic marker in the context of HIV infection.
In some cases, treatment is interrupted according to a scheduled time frame, while other studies have used CD4 T cell counts or viral load as indicators of when to stop or re-initiate therapy.
SIRT1 increases during the immunometabolic stage of sepsis coordinates innate tolerogenic dendritic cell and CD4 T cell repressor and immune inhibitory IL10 and TGF[beta] cytokines.
One of the first indications of this premise was the observation that viral loads increase and CD4 T cell counts fall in patients stopping therapy.