Data from one such patient was available at the data cutoff and showed neoantigen-specific CD8 T-cell
responses were detected to 10 out of 18 class I neoantigens after the 4th dose of the vaccine (compared to 0/18 at baseline).
In vivo impact of cytomegalovirus evasion of CD8 T-cell
immunity: facts and thoughts based on murine models.
Kim et al., "Pan-cancer immunogenomic perspective on the tumor microenvironment based on PD-L1 and CD8 T-cell
infiltration," Clinical Cancer Research, vol.
Cooperation of Tim-3 and PD-1 in CD8 T-cell
exhaustion during chronic viral infection.
Nomdedeu et al., "Immunological profile of heterosexual highly HIV-exposed uninfected individuals: predominant role of CD4 and CD8 T-cell
activation," The Journal of Infectious Diseases, vol.
Indeed, experiments in a mouse model of influenza A infection showed that animals that had consumed 18 to 20 percent ethanol for 4 to 8 weeks exhibited an impaired influenza-specific CD8 T-cell
To that end, Professor Esteban Celis (at GRU) first reported that in animal models a dsRNA analogue of Ampligen, Poly I: Poly C, significantly increased survival in animal tumors when administered in combination with PD-1 inhibitors (see Combinatorial Immunotherapy of Poly I - Poly C and Blockage of Program Death- Ligand 1 Induce Effective CD8 T-Cell
Responses in Established Tumors, Clin Cancer Research, 2014).
Viral persistence alters CD8 T-cell
immunodominance and tissue distribution and results in distinct stages of functional impairment.
It induces rapid growth of immune cells such as CD4 and CD8 T-cell
populations that aid destruction of the AIDS-causing virus.
After stimulation with ConA for 72 h, the effects of NNAV on CD4 or CD8 T-cell
division were analyzed by gating on CD[4.sup.+] or CD8+ subsets of T cells.
Ahmed, "Viral persistence alters CD8 T-cell
immunodominance and tissue distribution and results in distinct stages of functional impairment," Journal of Virology, vol.