CD4

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Related to CD8 count: CD4 cells

CD4

 (sē′dē-fôr′)
n.
A glycoprotein that is found on the surface of T cells, especially helper T cells, and functions as a receptor in activation of the cells. In humans, HIV gains entry to helper T cells by binding to the CD4 receptor.

[c(luster of) d(ifferentiation antigen) 4.]
American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.

CD4


n.
a protein on the surface of T cells and other cells, functioning as a receptor for the AIDS virus antigen.
[1980–85; c(luster of) d(ifferentiation) 4]
Random House Kernerman Webster's College Dictionary, © 2010 K Dictionaries Ltd. Copyright 2005, 1997, 1991 by Random House, Inc. All rights reserved.
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.CD4 - a glycoprotein that is found primarily on the surface of helper T cells; "CD4 is a receptor for HIV in humans"
glycoprotein - a conjugated protein having a carbohydrate component
Based on WordNet 3.0, Farlex clipart collection. © 2003-2012 Princeton University, Farlex Inc.
References in periodicals archive ?
Selected parameters in this study are CD4, CD8 count, myeloperoxidase (MPO), and C-reactive protein estimation (CRP).
Independent predictors of lung cancer in US veterans, 1998-2012 * Variable Hazard ratio (95% confidence interval) CD4 count 100 to 199 (vs over 500) 2.3 (1.6 to 3.4) CD4 count 200 to 500 (vs over 500) 1.2 (1.2 to 2.1) CD8 count over 1000 (vs under 600) 1.5 (0.9 to 2.1) CD8 count 600 to 1000 (vs under 600) 1.4 (1.0 to 2.3) CD4/CD8 ratio below 0.4 (vs above 1.0) 2.6 (1.6 to 4.1) CD4/CD8 ratio 0.4 to 1.0 (vs above 1.0) 1.9 (1.2 to 3.0) Viral load above 500 (vs under 500) 1.4 (1.1 to 1.9) Bacterial pneumonia, 2 of more episodes (vs 0) 1.8 (1.0 to 2.5) Bacterial pneumonia, 1 episode (vs 0) 1.7 (1.2 to 2.4) * 12-month lagged analysis.
Other laboratory findings are variable but may include a slightly elevated or normal CD8 count, CBC differential demonstrating lymphopenia, and normal or slightly low immunoglobulin levels.
CD4 count of 68 and CD8 count of 140 was seen in one case of splenomegaly with lymphadenopathy.
IMW+ patients had been under HAART for a longer period of time, had a significantly lower CD4 count, but no difference in the CD8 count, resulting in a lower CD4/CD8 ratio.
The patient's IgA IgM and IgE levels and the results of a lymphocyte subset analysis were normal (CD19 CD4 count CD8 count and CD4/CD8 ratio).
Among subjects with normal weight, Group AN has the highest average increase in level of CD8 count followed by Group BN and Group CN, while, for those who are underweight, Group AU has the highest increase in CD8 count followed by Groups BU and CU.
He was HIV negative with a CD4 count of 1 cell/[micro]l (normal 500 - 2 010), a CD8 count of 2 cells/[micro]l (normal 250 - 990), a CD3 count of 3 cells/[micro]l (normal 699 - 3 001) and a CD4/CD8 ratio of 0.500.
The mean haematological parameters revealed a significant increase in total white blood cell, CD4, CD8 count and significant decrease in the packed cell volume of child subjects in relation to adolescent and adult subjects (p<0.05).
The patient was followed up until August 2009 with a favourable outcome; at that visit he had a viral load of <400 copies/ml, a CD4 count of 332 cells/ul and a CD8 count of 632 cells/[micro]l.
The CD8 count was a median of 780 with a range of 483-2 056.