As Skp2 mediates the ubiquitination degradation of many negative regulators of cell proliferation such as p27, p21, p53, and p57 (also known as CDKN1C
), upregulated Skp2 is associated with rapid growth and immortalization of cancer cells (5).
(2017) used a mouse model to identify that the placental expression of paternally expressed gene 10 (PEG10) can be significantly downregulated and cyclin dependent kinase inhibitor 1C (CDKN1C
) significantly up-regulated in response to higher prenatal Cd exposures (Xu et al.
p57 is the gene product of the paternally imprinted, maternally expressed gene CDKN1C
, a cyclin-dependent kinase inhibitor located on chromosome 11p15.5.
Cell cycle genes PEDF and CDKN1C
in growing deer antlers.
Active EZH2 induces and activates, in conjunction with HMGA, tumour-promoting factors and proliferation, repressing differentiating factors such as runt-domain transcription 3 factor (RUNX3), p57 cyclin-CDK inhibitor 1C (CDKN1C
), and cadherin 1 (CDH1) [28, 42-49].
The H19 (103280), ICR1 (616186), and KCNQ1OT1 (604115) are located at 11p15.5; and the CDKN1C
(60856) is located at 11p54 [1, 7, 8].
This syndrome develops as a result of impaired expression of a cell cycle regulator protein, cyclin dependent kinase inhibitor 1C (CDKN1C
Genes Tested AtP ALK APC ATM BAP1 BRCA2 BRIP1 BUB1B CDC73 CDH1 CEP57 CHEK2 CYLD DDB2 DICER1 ERCC3 ERCC4 ERCC5 EXT1 EXT2 FANCD2 FANCE FANCF FANCG FANCI GATA2 GPC3 HNF1A HOXB13 HRAS MLH1 MHS2 MSH6 MUTYH NBN PHOX2B PMS1 PMS2 PPM1D PRF1 RAD51D RBI RECQL4 RET RHBDF2 SDHC SDHD SLX4 SMAD4 SMARCA4 TP53 TSC1 TSC2 VHL WT1 BARD1 BLM BMPR1A BRCA1 CDK4 CDKN1C
CDKN2A CEBPA DI53L2 EGFR EPCAM ERCC2 EZH2 FANCA FANCB FANCC FANCL FANCM FH FLCN KIT MAX MEN1 MET NF1 NF2 NSD1 PALB2 PRKAR1A PTCH1 PTEN RAD51C RUN XI SBDS SDHAF2 SDHB SMARCB1 STK11 5UFU TMEM127 WRN XPA XPC This chart shows all 98 cancer susceptible genes included in this new test.