complement fixation

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complement fixation

n.
The binding of active serum complement to an antigen-antibody pair. It is the basis for various diagnostic tests to detect the presence of a specific antigen or antibody.

com′plement fixa`tion



n.
the binding of complement to immune complexes or to certain foreign surfaces, as those of invading microorganisms.
[1905–10]
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.complement fixation - an immune response in which an antigen-antibody combination inactivates a complement (so it is unavailable to participate in a second antigen-antibody combination)
immune reaction, immune response, immunologic response - a bodily defense reaction that recognizes an invading substance (an antigen: such as a virus or fungus or bacteria or transplanted organ) and produces antibodies specific against that antigen
References in periodicals archive ?
Few public Brazilian schools have a track or a space sufficiently large enough to perform a CF test.
Assignment of clinical impact indeed continues to be a challenge for certain mutations in any CF test, especially missense mutations of relatively low frequency for which functional studies have not been performed and clinical correlations are not obvious.
initial EIA IgM positive, IgG negative, ID negative, CF negative followed by a positive result of [greater than or equal to]1 of the following: EIA IgG, ID, CF); or 3) an increase in serologic titer on the second CF test.
Thus, it appears that something very different was happening when participants responded to the stimuli to which they were exposed during training compared to those that were never encountered until the CF test phase.
Diagnosis almost always is established by using serologic methods in which paired sera are tested for Chlamydia antibodies by CF test.
Additionally, like the first generation xTAG CF test, the new xTAG Cystic Fibrosis 39 Kit v2 does not require reflex testing.
All of the blood samples taken from the infected prairie dogs (Table 1) were examined by CF test for monkeypox virus antibodies, by using a vaccinia antigen.
The presence of antibodies against WNV was evaluated using the CF test and by an immunoglobulin (Ig)G enzyme-linked immunosorbent assay (ELISA) technique.
In 2004, with a growth rate of more than 30% per year, approximately 300,000 maternal screening tests for CF were performed in the United States, resulting in an estimated CF test market of $42 million.