Cox-2 inhibitor

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COX-2 inhibitor

Any of a class of nonsteroidal anti-inflammatory drugs that selectively block prostaglandin formation so as to cause minimal gastrointestinal side effects.
American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.Cox-2 inhibitor - an anti-inflammatory drug that fights pain and blocks Cox-2 activity without impeding the activity of Cox-1; increases the risk of heart attacks; "Cox-2 inhibitors reduce the symptoms of arthritis without endangering the stomach and kidneys"
anti-inflammatory, anti-inflammatory drug - a medicine intended to reduce inflammation
Celebrex, celecoxib - a Cox-2 inhibitor (trade name Celebrex) that relieves pain and inflammation without harming the digestive tract
rofecoxib, Vioxx - a Cox-2 inhibitor (trade name Vioxx) that relieves pain and inflammation without harming the digestive tract; voluntarily withdrawn from the market in 2004
Bextra, valdecoxib - a Cox-2 inhibitor (trade name Bextra) that relieves pain and inflammation without harming the digestive tract
Based on WordNet 3.0, Farlex clipart collection. © 2003-2012 Princeton University, Farlex Inc.
References in periodicals archive ?
However, after those high levels fall, patients taking diclofenac spend a substantial period of time with unopposed COX-2 inhibition, a state that is known to be prothrombotic, and also associated with blood pressure elevation, atherogenesis, and worsening of heart failure.
For example, the association between an increased expression of COX-2 and tumor angiogenesis (20) and the antiangiogenic effects of COX-2 inhibition by CX, mediated through the inhibition of VEGF expression, has been previously demonstrated.
In theory, the mechanism by which meloxicam exerts its analgesic effect is via selective COX-2 inhibition as demonstrated in studies of systemic administration.
COX-2 inhibition interferes with [beta]-amyloid cascade that mediates the suppression of memory and synaptic plasticity.
Citation: Ramasatyaveni Geesala et al., "Cox-2 inhibition potentiates mouse bone marrow stem cell engraftment and differentiation-mediated wound repair," Cytotherapy, 2017; 19 (6): 756
Carcinogenesis and cyclooxygenase: The potential role of COX-2 inhibition in upper aerodigestive tract cancer.
Unexplained antipyretic and analgesic effects of acetaminophen, phenacetin, and dipyrone, without evident COX-1 or COX-2 inhibition, were made clear by the discovery of yet another COX isoenzyme termed COX-3 that when expressed showed selective inhibition to these agents [17].
Massaro et al., "Mediterranean diet polyphenols reduce inflammatory angiogenesis through MMP-9 and COX-2 inhibition in human vascular endothelial cells: a potentially protective mechanism in atherosclerotic vascular disease and cancer," Archives of Biochemistry and Biophysics, vol.
NSAIDs act mainly through the inhibition of COX activity in the biochemical cascade that leads to prostaglandin synthesis, and there are selective NSAIDs for COX-2 inhibition (KHWANJAI et al., 2011).
(2010) and concluded that COX-2 inhibition resulted in decrease production of anti-bodies against the virus.
To examine whether TRPA1 activation is involved in COX-2 inhibition by methyl syringate, we examined whether the selective TRPA1 antagonist F1C-030031 blocked the effects of methyl syringate on COX-2 protein expression.