Cox-2 inhibitor

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COX-2 inhibitor

n.
Any of a class of nonsteroidal anti-inflammatory drugs that selectively block prostaglandin formation so as to cause minimal gastrointestinal side effects.
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.Cox-2 inhibitor - an anti-inflammatory drug that fights pain and blocks Cox-2 activity without impeding the activity of Cox-1; increases the risk of heart attacks; "Cox-2 inhibitors reduce the symptoms of arthritis without endangering the stomach and kidneys"
anti-inflammatory, anti-inflammatory drug - a medicine intended to reduce inflammation
Celebrex, celecoxib - a Cox-2 inhibitor (trade name Celebrex) that relieves pain and inflammation without harming the digestive tract
rofecoxib, Vioxx - a Cox-2 inhibitor (trade name Vioxx) that relieves pain and inflammation without harming the digestive tract; voluntarily withdrawn from the market in 2004
Bextra, valdecoxib - a Cox-2 inhibitor (trade name Bextra) that relieves pain and inflammation without harming the digestive tract
References in periodicals archive ?
The Vioxx Gastrointestinal Outcomes Research (VIGOR) trial, published in 2000, was the first to raise concerns that NSAIDs (specifically, the COX-2 selective inhibitor rofecoxib) might be associated with a higher risk for cardiovascular (CV) events.
To observe whether or not the higher expression of COX-2 contributed to H/R-induced cell injury in H9C2 cardiomyocytes, the cells were incubated with the COX-2 selective inhibitor, NS398, before being subjected to H/R.
MEDAL involved more than 34,000 patients with rheumatoid arthritis or osteoarthritis who were randomized to receive treatment with either the COX-2 selective inhibitor etoricoxib or diclofenac.
The revised guideline recommends the eradication of Helicobacter pylori prior to initiating NSAIDs for pain, and the use of a proton pump inhibitor or misoprostol for gastrointestinal protection in older persons taking nonselective NSAIDs or in patients taking a COX-2 selective inhibitor with aspirin.
The MEDAL (Multinational Etoricoxib and Diclofenac Arthritis Long-term) programme provides a randomised comparison of the COX-2 selective inhibitor etoricoxib and the traditional NSAID diclofenac in 34 701 osteoarthritis and rheumatoid arthritis patients followed up for a mean duration of 18 months.
More importantly, inhibition of COX-2 activity using the COX-2 selective inhibitor, NS398 results in a dose-dependent attenuation of A[beta]-induced cell death (Fig.
Cox-2 selective inhibitor is a form of NSAID that directly targets cyclooxygenase-2, an enzyme responsible for inflammation and pain and devoid of side effects of Cox-1 enzyme inhibition like less gastrointestinal toxicity and no effects on platelet aggregation.
In theory a COX-2 selective inhibitor should have the benefits of tocolysis without these side effects, said Dr.
For this reason, lack of satisfactory pain relief with one NSAID or COX-2 selective inhibitor does not preclude the possible benefit of treatment with another.
In theory, a COX-2 selective inhibitor should have the benefits of tocolysis without these side effects, said Dr.
The study found no significant association between cardiac arrest and the COX-2 selective inhibitors celecoxib and rofecoxib, or with the unselective NSAID naproxen.
Although the duration of treatment is still empirical, it is known that it should be prolonged, since COX-2 selective inhibitors are capable of inhibiting receptor activation, but do not show any effect in receptor expression (LAVALLE et al.