Cox-2 inhibitor

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COX-2 inhibitor

Any of a class of nonsteroidal anti-inflammatory drugs that selectively block prostaglandin formation so as to cause minimal gastrointestinal side effects.
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.Cox-2 inhibitor - an anti-inflammatory drug that fights pain and blocks Cox-2 activity without impeding the activity of Cox-1; increases the risk of heart attacks; "Cox-2 inhibitors reduce the symptoms of arthritis without endangering the stomach and kidneys"
anti-inflammatory, anti-inflammatory drug - a medicine intended to reduce inflammation
Celebrex, celecoxib - a Cox-2 inhibitor (trade name Celebrex) that relieves pain and inflammation without harming the digestive tract
rofecoxib, Vioxx - a Cox-2 inhibitor (trade name Vioxx) that relieves pain and inflammation without harming the digestive tract; voluntarily withdrawn from the market in 2004
Bextra, valdecoxib - a Cox-2 inhibitor (trade name Bextra) that relieves pain and inflammation without harming the digestive tract
References in periodicals archive ?
MEDAL involved more than 34,000 patients with rheumatoid arthritis or osteoarthritis who were randomized to receive treatment with either the COX-2 selective inhibitor etoricoxib or diclofenac.
The revised guideline recommends the eradication of Helicobacter pylori prior to initiating NSAIDs for pain, and the use of a proton pump inhibitor or misoprostol for gastrointestinal protection in older persons taking nonselective NSAIDs or in patients taking a COX-2 selective inhibitor with aspirin.
In particular, the use of COX-2 selective inhibitor NSAIDs continues to raise the concern of cardio-renal complications not only in the decision making process of physicians but also in the perception of many patients who still recall the media blitz of reports surrounding the cardiovascular complications associated with the long term use of Vioxx and other "COX-2" analgesics.
The MEDAL (Multinational Etoricoxib and Diclofenac Arthritis Long-term) programme provides a randomised comparison of the COX-2 selective inhibitor etoricoxib and the traditional NSAID diclofenac in 34 701 osteoarthritis and rheumatoid arthritis patients followed up for a mean duration of 18 months.
More importantly, inhibition of COX-2 activity using the COX-2 selective inhibitor, NS398 results in a dose-dependent attenuation of A[beta]-induced cell death (Fig.
In theory a COX-2 selective inhibitor should have the benefits of tocolysis without these side effects, said Dr.
Basel, Switzerland -- Basel, Switzerland, June 20 /PRNewswire/ -- Data from key clinical Phase III studies presented for the first time at EULAR, the European League Against Rheumatism annual congress in Lisbon, demonstrate that Prexige(r) (lumiracoxib), a novel COX-2 selective inhibitor, provides effective relief of the symptoms of osteoarthritis (OA).
Novartis announced today that applications for regulatory approval of a novel COX-2 selective inhibitor, Prexige(R) (lumiracoxib), have been filed in the USA and the European Union.