Cox-2 inhibitor

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COX-2 inhibitor

n.
Any of a class of nonsteroidal anti-inflammatory drugs that selectively block prostaglandin formation so as to cause minimal gastrointestinal side effects.
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.Cox-2 inhibitor - an anti-inflammatory drug that fights pain and blocks Cox-2 activity without impeding the activity of Cox-1; increases the risk of heart attacks; "Cox-2 inhibitors reduce the symptoms of arthritis without endangering the stomach and kidneys"
anti-inflammatory, anti-inflammatory drug - a medicine intended to reduce inflammation
Celebrex, celecoxib - a Cox-2 inhibitor (trade name Celebrex) that relieves pain and inflammation without harming the digestive tract
rofecoxib, Vioxx - a Cox-2 inhibitor (trade name Vioxx) that relieves pain and inflammation without harming the digestive tract; voluntarily withdrawn from the market in 2004
Bextra, valdecoxib - a Cox-2 inhibitor (trade name Bextra) that relieves pain and inflammation without harming the digestive tract
References in periodicals archive ?
This researcher therefore suggested that factors to consider for patient safety include the direct effects of nonselective NSAIDs and of COX-2-selective inhibitors on fluid retention and blood pressure, differences among these agents with regard to associated gastrointestinal adverse event rates and the utility of simultaneous anti-inflammatory therapies with gastroprotective agents such as proton pump inhibitors when patients require cardioprotective doses of aspirin.
The risks for GI damage associated with the use of NS-NSAIDs has been somewhat mitigated by the availability of COX-2-selective inhibitors and by proton pump inhibitors.
In any case, COX-2-selective inhibitors should be used only in patients at high risk of gastrointestinal complications, he added.