The researchers found that, for every 500 MET-mins/week increase in physical activity from being totally sedentary, the risk of death was reduced by 14% in people with CVD
and 7% in those without it.
European guidelines on the prevention of CVD
do not recommend aspirin for individuals free from CVD
due to the increased risk of major bleeding.(2) This advice was subsequently supported by results in moderate risk patients (ARRIVE),(3) diabetic patients (ASCEND),(4) and in people over 70 (ASPREE) which demonstrated that modest reductions in CVD
risk were outweighed by the increased bleeding hazard.(5)
Compared to people without CVD
who did the most exercise, the increased risk was 87 per cent and 45 per cent for people with CVD
who had a totally sedentary lifestyle and for those who did 0-499 MET-mins/week, respectively.
This trial involved 8,179 patients with CVD
or diabetes plus other risk factors and LDL levels of 40-100 mg/dL on statin therapy.
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It takes at least five to 10 years and perhaps up to 25 years after quitting, for CVD
risk to become as low as that of a person who has never smoked, according to the study published in the Journal of the American Medical Association (JAMA).
Lopez, Ph.D., and Tim Adair, Ph.D., from the University of Melbourne in Australia, used vital statistics since 2000 for 23 high-income countries to examine age-standardized CVD
death rates by sex for all ages.
There are nearly 1.5 million such CVD
events in the UK each year.
Previous randomized trials haven't raised much concern, but they included prior users who may have developed patients with baseline CVD
But European guidelines released in 2016 stated that the drug is not recommended for primary prevention, and the US also imposed stricter regulations in administering aspirin to individuals that are at high-risk for CVD
. This means that those who do not have any CVD
are not advised to take aspirin as a preventive measure as it can increase the risk of bleeding.
Focusing on CVD
, which is the leading cause of deaths in the UAE, Dr Shehab said: "The UAE has all the risk factors for CVD