whim

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Related to CXCR4: CCR5

whim

(wĭm, hwĭm)
n.
1. A sudden or capricious idea; a fancy: "More than five hundred of these men would never see another sunset, yet a holiday atmosphere prevailed; they joked with each other as they marched, dropping out again for blackberries when the whim struck them, despite stern new orders to the contrary" (William Marvel).
2. Arbitrary thought or impulse: "I dreamed of having the golden flesh, the huge muscles of half-naked gods and goddesses who did whatever they wanted to do, ruling the universe according to their whims" (John Edgar Wideman).
3. A vertical horse-powered drum used as a hoist in a mine.
Idiom:
on a whim
Done suddenly or impulsively: "I just took a trip. Lit off at night, drove six hundred miles to see an old friend, on a whim" (Marya Hornbacher).

[Short for whim-wham, fanciful object.]

whim

(wɪm)
n
1. a sudden, passing, and often fanciful idea; impulsive or irrational thought
2. (Mining & Quarrying) a horse-drawn winch formerly used in mining to lift ore or water
[C17: from whim-wham]

whim

(ʰwɪm, wɪm)

n.
1. a capricious notion; fancy: a party thrown on a whim.
2. capricious humor.
[1635–45; short for Middle English whim-wham, gradational compound]
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.whim - a sudden desire; "he bought it on an impulse"
desire - the feeling that accompanies an unsatisfied state
2.whim - an odd or fanciful or capricious idea; "the theatrical notion of disguise is associated with disaster in his stories"; "he had a whimsy about flying to the moon"; "whimsy can be humorous to someone with time to enjoy it"
idea, thought - the content of cognition; the main thing you are thinking about; "it was not a good idea"; "the thought never entered my mind"

whim

noun impulse, sudden notion, caprice, fancy, sport, urge, notion, humour, freak, craze, fad (informal), quirk, conceit, vagary, whimsy, passing thought, crotchet We decided, more or less on a whim, to sail to Morocco.

whim

noun
An impulsive, often illogical turn of mind:
Translations
نَزْوَه
indfaldpåfund
oikku
duttlungur
įnoris
kaprīzeuntums
geçici istekkapris

whim

[wɪm] Ncapricho m, antojo m
a passing whimun capricho pasajero, un antojo
it's just a whim of herses un capricho suyo
as the whim takes mesegún se me antoja

whim

hwɪm] ncaprice m
on a whim → sur un coup de tête
at the whim of sb → sur un caprice de qn

whim

nLaune f; her every whimjede ihrer Launen; at or on whim, at or on a whimaus Jux und Tollerei (inf); as the whim takes me etcganz nach Lust und Laune

whim

[wɪm] ncapriccio
a passing whim → una passione momentanea
as the whim takes me → come mi gira

whim

(wim) noun
a sudden desire or change of mind. I am tired of that child's whims.
References in periodicals archive ?
The company's oral small molecule drug candidates antagonize the CXCR4 pathway, which plays a central role in immune surveillance.
Effector cells: CD62L, CD44, CD45RA, CD45RO, CD27, CD28, CD69, Costimulatory molecules CTLA4, ICOS, FAS, PD-1, CD25, CD127, - chemokine receptors CCR7, CCR4, CXCR3, CXCR4, CXCR5, CCR6, CX3CR1, - apoptosis / living dead differentiation annexin, live dye z.
- The European Commission, based on a favourable recommendation from the European Medicines Agency's Committee for Orphan Medicinal Products, has granted orphan drug designation to mavorixafor (X4P-001) for the treatment of WHIM (Warts, Hypogammaglobulinemia, Infections, and Myelokathexis) syndrome, a rare, inherited, primary immunodeficiency disease caused by genetic mutations in the CXCR4 receptor gene, US-based biopharmaceutical company X4 Pharmaceuticals, Inc.
The company said, "As we progress through 2019, we are approaching important data milestones with our lead program, the CXCR4 antagonist BL-8040, in two cancer indications with high unmet medical need.
In our previous study, we reconstructed an associative network for TB and revealed novel candidate genes including CD4, CD69, CD79, CD80, MUC16, HCST, ADA, CP, SPP1, CXCR4, AGER, and PACRG.
It functions as a high-affinity best-in-class antagonist for CXCR4, a chemokine receptor that is directly involved in tumour progression, angiogenesis, metastasis and cell survival.
WHIM syndrome is a primary immunodeficiency disorder characterized by panleukopenia and caused by autosomal dominant gain-of-function mutations in CXC chemokine receptor 4 (CXCR4).
A number of studies have shown that the BMSCs migrate to sites of injury and inflammation in response to soluble mediators including the chemokine stromal cell-derived factor (SDF-1), but during in vitro culture expansion BMSCs lose surface expression of key promoting homing receptors particularly SDF-1[alpha] receptor, cognate receptor CXC chemokine receptor 4 (CXCR4) (10).
[ELR.sup.-] chemokines are commonly angiostatic, but CXCL12 (previously known as stromal cell-derived factor 1, abbreviated as SDF1) [10] and its receptor, CXCR4 (previously known as LESTR, fusion, or CD184), are reported to promote angiogenesis and play a major role in metastasis.
SDF1 binds to CXCR4 on the surface of ciPC and recruits them to the sites of vascular injury.
The migration activity of DCs was investigated by determining the mRNA expression of chemokine mRNA of CCR7 and CXCR4. Total RNA was extracted using Trizol Reagent (Invitrogen, Carlsbad, CA, USA).