In addition to GJB2, >80 mutations in MYO7A (OMIM: 276903) encoding myosin VIIA have also been linked with syndromic and NSHL.11 MYO7A co-ordinates between the transduction channel and stereocilia membrane and interact with hair cells by associating with cadherin
Cell Cycle DNA test plus reagent Kit and Annexin V apoptosis detection kit were from BD, Pharmingen (USA) and phalloidine, Anti-E cadherin
were obtained from Thermo Scientific (USA).
Several studies have established a link between the gene that encodes T-cadherin, cadherin
13, and various metabolic diseases [32-34].
Caption: Figure 7: Effects of SB-431542 treatment on the expression of E- cadherin
, vimentin, and collagen type by RT-PCR and Western blot.
The topics include the integration of cadherin
adhesion and cytoskeleton at adherens junction, making connections: guidance cues and receptors at non-neural cell-cell-junctions, tuning collective cell migration by cell-cell junction regulation, beyond cell-cell adhesion: sensational cadherins
for hearing and balance, and the loss of E-cadherin-dependent cell-cell adhesion and the development and progression of cancer.
All CDH genes (n = 27) screened in this study include CDH1 (E-cadherin), CDH2 (N-cadherin), CDH3 (P-cadherin), CDH4 (R-cadherin), CDH5 (VE-cadherin), CDH6 (K-cadherin), CDH7 (cadherin
7), CDH8 (cadherin
8), CDH9 (T1-cadherin), CDH10 (T2-cadherin), CDH11 (OB-cadherin), CDH12 (N-cadherin 2), CDH13 (H-cadherin), CDH15 (M-cadherin), CDH16 (KSP-cadherin), CDH17 (LI-cadherin), CDH18 (cadherin
18), CDH20 (cadherin
20), PCDHGA12 (CDH21), CDH22 CDH23 CDH24 DCHS1 (CDH19, or CDH25), CDH26 DCHS2 (CDH27), CDHR3 (CDH28), and CDHR4 (CDH29).
The loss of E- Cadherin
, alpha- and beta- catenin expression is associated with metastasis and poor prognosis in invasive breast cancer.
The GLE suppressed the TGF-[beta]1 -induced morphological changes and the changes in cadherin
expression, and also inhibited the formation of F-actin stress fibers, which are a hallmark of EMT.
E-cadherin is a member of the cadherin
superfamily, serving as the main epithelial intercellular adhesion molecule.
Center cells lost the expression of octamer-binding transcription factor 4 (OCT4) and epithelial cadherin
(E-cadherin) faster than perimeter cells, which are critical to the development of heart tissue.