TEHRAN (FNA)- In a new study, researchers administered an antidepressant called mianserin to Caenorhabditis elegans
, a type of roundworm used frequently in research.
We will use the nematode Caenorhabditis elegans
as a model organism to identify novelconserved genes, molecules, and metabolic networks that link reproduction and longevity throughnutrition.
Using these nematodes, called Caenorhabditis elegans
, Falk's research laboratory has done extensive studies to understand mitochondrial disease and potential therapies.
Epigallocatechin gallate inhibits beta amyloid oligomerization in Caenorhabditis elegans
and affects the daf-2/insuIin-like signalling pathway.
Experts tweaked two genetic pathways in the tiny lab worm Caenorhabditis elegans
and boosted the creature's lifespan by a factor of five.
The team details its technology and early results in the paper "High-throughput imaging of neuronal activity in Caenorhabditis elegans
,'' published online in advance of print by the journal Proceedings of the National Academy of Sciences.
Growing evidence indicates that fipronil may inhibit GluCls of invertebrates generally, because it does so in the nematode, Caenorhabditis elegans
Maupas (Horoszok et al.
Investigation of CED-1 receptor in bacterial pathogen recognition of Caenorhabditis elegans
infected with Acinetobacter baumannii.
Withania somnifera root extract extends lifespan of Caenorhabditis elegans
However, longevity in Caenorhabditis elegans
is related to activity levels, possibly through maintenance of mitochondrial function throughout the life span.
Dr Weinkove said: "Our project will use the non-parasitic worm Caenorhabditis elegans
, which can be genetically modified to produce proteins found in parasitic worms, but does not need a host to grow in, thereby replacing the use of rodents.
Therefore, we supplemented plasma samples with Caenorhabditis elegans
miR-39 (cel-miR-39), as described previously (4).