IX, a hypoxiainduced catalytic component of the pH regulating machinery in tumors.
Zinc metallo-enzymes carbonic anhydrases
(CAs, EC 4.
Two pivotal adaptations related to maintaining intracellular pH homeostasis in an acidic environment, have recently received significant attention: (1) the presence of chronic autophagy in tumors and (2) the overexpression of carbonic anhydrases
(CAs), mainly CA IX and CA XII.
The carbonic anhydrases
(CA), members of the zinc metalloprotein family, are enzymes which catalyze the interconversion of carbon dioxide and water to bicarbonate and hydrogen ions.
Hydroides elegans carbonic anhydrases
1 and 2 (HeCAl and HeCA2, respectively) were 2 of 12 HeCA genes identified from recovered contigs in the transcriptomes.
1994), glucocorticoids are able to accelerate the enzymatic activity of carbonic anhydrases
(Donn et al.
Esterase activities of human carbonic anhydrases
B and C.
Down-regulation of transmembrane carbonic anhydrases
in renal cell carcinoma cell lines by wild-type von Hippel-Lindau transgenes.
The proteins, enzymes called carbonic anhydrases
, split CO2 into bicarbonate and protons.
Diagnostic, prognostic and therapeutic implications of carbonic anhydrases
Major drug targets like carbonic anhydrases
, matrix metalloproteinases, bacterial proteases, angiotensin-converting enzyme, histone deacetylase, and APOBEC3G
Supuran, The Alpha and Beta Classes' Carbonic Anhydrases
from Helicobacter pylori as Novel Drug Targets, Curr.