They most commonly occur in the intestine, where they are often called carcinoid tumors
, but they are also found in the pancreas, lung and the rest of the body.
1) Carcinomas with neuroendocrine features are subclassified into 3 groups: well-differentiated neuroendocrine tumor (WD-NET), which are low-grade tumors that architecturally resemble carcinoid tumors
of other sites; poorly differentiated neuroendocrine carcinoma (PD-NEC) or small cell carcinoma, which is identical to its pulmonary counterpart; and invasive breast carcinoma with neuroendocrine differentiation (IBC-NED), which is a breast carcinoma of special or no special type that demonstrates neuroendocrine differentiation by immunohistochemistry.
DP1038 leverages patented technology for enhanced intranasal absorption developed by Aegis Therapeutics, LLC, and is being developed as a non-injectable alternative for the treatment of patients with acromegaly and the symptomatic treatment of patients with carcinoid tumors
Also, in four patients with paraganglioma, pheochromocytoma, parathyroid adenoma, and carcinoid tumors
, who were monitored throughout their treatment course, CgA dropped sharply in the post-treatment phase within days, weeks or months, depending on the tumor.
The company said Carcinoid syndrome occurs when metastatic carcinoid tumors
overproduce certain chemicals, including serotonin.
Although carcinoid tumors
are rare, they are the most common form of gut neuroendocrine tumors.
However, they are negative for the KIT (CD117), associated with GISTs, and the chromogranin antigens, associated with carcinoid tumors
It is plausible that carcinoid tumors
may present by appendicitis because of luminal obstruction or elevated levels of 5 hydroxytryptamine, histamine and kinin.
are a heterogeneous group of neuroendocrine tumors whose clinical characteristics and behavior vary based on the primary site of origin, as each is derived from different precursor cells.
Although most discussions about appendiceal cancers have revolved around carcinoid tumors
historically, incidences of the noncarcinoid subtypes have been found to be higher as a whole, with rates per 1 million people per year of 1.
There is strong evidence that DIPNECH leads to carcinogenesis in case of pulmonary carcinoid tumors
, so suggestions were made to alter the classification of pulmonary neuroendocrine tumors by dividing them in two groups, one consisting of typical and atypical carcinoids as low-grade malignancies of the lung originating from DIPNECH and the other, containing the high-grade malignant neoplasms, like the small-cell carcinoma and the large-cell neuroendocrine carcinoma of the lung [2-5].
The Cushing syndrome induced by bronchial carcinoid tumors