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Other researchers found that cardiomyocytes (cardiac muscle cells) in the heart and in the blood vessels of rats matured according to the same clock, despite being distant from each other in the body.
These cells are called cardiomyocytes, and losing them puts people at risk of heart failure - a condition wherein the heart cannot pump blood effectively to the rest of the body.
Once the heart is fully formed, the cells that make up heart muscle, known as cardiomyocytes, have very limited ability to reproduce themselves.
The research effort will focus on developing allogeneic (non-patient) cardiomyocytes from induced pluripotent stem cells (iPSCs).
The coculture system was dealt with SI and SIR treatments to test the effect on cardiomyocytes survival.
We sought to demonstrate this approach using iPSC-derived cardiomyocytes, which have emerged as a particularly attractive and valuable in vitro model for cardiotoxicity testing (Blinova et al., 2017; Strauss et al., 2017; Burridge et al., 2016; Sharma et al., 2017; Kawatou et al., 2017).
The work could provide scientists a streamlined method to arrive at functioning heart cells (cardiomyocytes) for both research and regenerative therapies.
Cardiomyocytes, the principal cell type found in the heart orchestrates the cardiac contractions and ensures efficient blood flow throughout the body.
Heart failure (HF), the leading cause of death and hospitalizations worldwide, results from a myriad of cardiovascular diseases that lead to the death or dysfunction of cardiomyocytes. With a prevalence of 38 million people worldwide, it places a significant financial burden on health care systems, with an estimated $30 billion of annual spending in just the United States alone [1, 2].
It has been shown that cardiomyocytes rapidly change from the proliferative state into hypertrophy at postnatal day 3 or 4 [1].