caspase

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Related to Caspases: apoptosis, cytochrome c, Bcl-2

caspase

(ˈkæspeɪz)
n
a type of enzyme that is involved in apoptosis and necrosis
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.caspase - any of a group of proteases that mediate apoptosis
peptidase, protease, proteinase, proteolytic enzyme - any enzyme that catalyzes the splitting of proteins into smaller peptide fractions and amino acids by a process known as proteolysis
References in periodicals archive ?
Caspases are proteolytic enzymes that can cause cell death by apoptosis, necrosis, and inflammation.
Currently most anti-cancer therapies (chemotherapy, radiation and immunotherapy) work by killing cancer cells through a process called apoptosis, which activates proteins called caspases, leading to cell death.
Currently most anticancer therapies (chemotherapy, radiation and immunotherapy) kill cancer cells through a process called apoptosis, which activates proteins called caspases, leading to cell death.
Metformin protect against PTZ-induced apoptotic neurodegeneration: Mitochondrial changes occurs after the activation of caspases pathway.
Table 2 shows the summary of the expression of protein apoptosis of T47D, such as p53, Bcl-2, Caspases 8 and 9.
The inflammasome is a large molecular platform that triggers the activation of inflammatory caspases and the processing of pro-interleukin-1[sz] (pro-IL-1[sz]) and pro-IL-18.
The caspases as a novel group of 10 cysteine proteases are the major enzymes involved in the process of apoptosis [21] and are responsible for execution of apoptosis [22].
Caspases are cysteine-containing aspartic acid-specific proteases which exist as zymogens in the soluble cytoplasm, endoplasmic reticulum (ER), mitochondrial intermembrane space, and nuclear matrix [10].
Activation of P53 death signals lead to Caspases activation and thus can induce apoptosis through release of mitochondrial Cytochrome c into the cytoplasm which then facilitates activation of Caspase 9, leading to activation of Caspase 3 and other effector caspases.
deistopholine stimulated both caspases 3 and 9 when the treatment time was increased from 24 to 72 h.
Compared with the MPTP group, although pretreatment with Sal significantly decreased the cleavage of these caspases to 2.
The apoptotic process is governed by cysteine aspartate specific proteases, termed caspases, that progressively disassemble the dying cell by the selective cleavage of cellular substrates involved in cytoskeleton reorganization and nuclear degradation [6].