active site

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active site

n.
The part of an enzyme at which catalysis of the substrate occurs.

ac·tive site

(ăk′tĭv)
The part of an enzyme where the substance that the enzyme acts upon (called the substrate) is catalyzed. See more at enzyme.
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.active site - the part of an enzyme or antibody where the chemical reaction occurs
site, situation - physical position in relation to the surroundings; "the sites are determined by highly specific sequences of nucleotides"
enzyme - any of several complex proteins that are produced by cells and act as catalysts in specific biochemical reactions
antibody - any of a large variety of proteins normally present in the body or produced in response to an antigen which it neutralizes, thus producing an immune response
References in periodicals archive ?
36-38) The residues only in the catalytic domain (Tyr-148, 199, 238, 307, and 341, and His-173, 179, 200, and 324) revealed chemical shift changes on AMPPNP/ATP binding.
Identification of a point mutation in the catalytic domain of the protooncogene c-kit in peripheral blood mononuclear cells of patients who have mastocytosis with an associated hematologic disorder.
Molecular docking studies revealed that 5-OH was accessible to the catalytic domain of UGTIAs; therefore, 5-OH exhibited a high probability of glucuronidation.
The results revealed two domains (Starch synthase, catalytic domain and Glycosyl transferase, family 1) in waxy protein of rice while only one domain (Starch synthase, catalytic domain) was found in maize (Fig.
The catalytic domain of human membrane type-1 matrix metalloproteinase (MMP) will be used as model enzyme.
The catalytic domain of FKBP38 binds to Bcl-2 through a charge-sensitive loop (Haupt et al.
PCSK9 has a signal peptide, a prosegment, and a catalytic domain but not a P-domain; instead there is a cysteine/histidine-rich domain in the C-terminal domain (Fig.
In the present study, we evaluate the 3-5-DCQA interaction (IUPAC name: (S)-2-((1R,3R,4R,5R)-3,5-bis((E)-3-(3,4-dihydroxyphenyl)acryloyloxy)- 4hydroxycyclohexyl)-2-hydroxyacetic acid) with the catalytic domain of Human T-Lymphotropic (HTLV-I) type I Integrase in the presence of [Mg.
The catalytic domain contains three putative catalytic residues ser154, asp178 and his248 encoded by exons 3, 4 and 6 respectively that are important for its catalytic activity.
Therefore, we report here the use of denaturing high performance liquid chromatography (dHPLC) and sequencing methods to screen for mutations in the nucleotide binding loop (P-loop), the catalytic domain and the activation loop of the ABL gene.
From the SCOP database it was found that all the caspase-3 proteins belongs to alpha and beta proteins and they are in the caspase catalytic domain family.