belong to the lysosomal cysteine proteinase family which play an essential role in the different cellular processes in bone remodeling and resorption (Turk et al.
Local acidic environments may increase the activity of cathepsins
(Cats) rather than that of MMPs.
lane E), it is assumed that cathepsins
L might trigger substrate hydrolysis and then, peptidases of the aspartic class continue in an orchestrated proteolytic mechanism.
belong to the cysteine protease family, and its presence was demonstrated in the samples analyzed.
Additionally, the main inhibitor of cathepsin
S, cystatin C, inhibits various cysteine proteinases including cathepsins
L and K, and lung production of these other cysteine proteinases is also increased in COPD patients .
Iron-mediated lysosomal ROS generation causes lysosomal membrane permeabilization (LMP)  and the ensuing release of cathepsins
into the cytosol and thereby induces apoptosis through activation of mitochondrial membrane permeabilization (MMP) .
Potential role(s) of cysteine cathepsins
in cancer progression and metastasis.
pH decline rate, metabolism, contraction rate, cathepsins
B and B+L activities and tenderness (myofibrillar toughness) were evaluated at different ageing times.
Proteases that have been chosen for this purpose are caspases, legumain and cathepsins
B, L and S for which I will synthesize very specific, small molecule radiolabeled inhibitors suitable for mass cytometry approach.
We hypothesize that cadmium induces lysosomes to permeabilize, release cathepsins
, leading to apoptosis in osteoblast-like cells Saos-2 and MG-63.
Apart from MMP, matrix and fibrous cap degradation is also activated by cathepsins
and other elastolytic enzymes (Table 1) .
Involvement of cathepsins
in the invasion, metastasis and proliferation of cancer cells.