Cedrol, widdrol, thujopsene, alpha cederene, beta cedrene
, and a range of sesquiterpenes are the key components involved in the China Cedar wood oil.
Category Main components Aromatic hydrocarbons Ethylbenzene, 1,3-dimethyl benzene, 1-methylene lH-indene, butylated hydroxy toluene, 1-methylnaphthalene, 2-methylnaphthalene Alkanes Undecane, dodecane, tridecane, tetradecane, pentadecane, hexadecane, 2,6,10-trimethyl dodecyl, 4-(prop-2 loxypropangl)octane, 2,6-dimethyl decane Alkenes 2-Propenylidene cyclobutene, cedrene
, Seychelles alkene Aldehydes and ketones Hexanal, nonanal, benzaldehyde, acetophenone, undecanal Esters Butyl butyrate, 3-methyl heptanol acetate, 2 acrylic acid 2 ethylhexyl ester, oxalic acid acrylate Others TV-butyl ether
XVI.1,2 constitution of patchouli alcohol and absolute configuration of cedrene
," Journal of the American Chemical Society, vol.
fragrantissima oil is rich with sesquisabinene hydrate, bisabolene epoxide, camphor, and caryophyllene oxide; also limonene, menthol, azulene, and thujone are found in moderate amount, while santolina alcohol, lanceol, cedrene
, and granny geraniol are found in a minor amounts (Table 1).
officinale consisted of 8% cedrene
46% Gingerol 7.32% a-
Rt % Monoterpene hydrocarbons (i) [alpha]-Pinene 4.40 1.95 (ii) dl-Limonene 6.33 0.96 (iii) [alpha]-Pinene 10.78 0.80 (iv) (+)-4-Carene 12.44 3.86 (v) Bicyclo[4.1.0]hept-2-ene, 12.81 0.71 3,7,7-trimethyl Rt % Sesquiterpene hydrocarbons (i) [alpha]-Cedrene 12.98 0.15 (ii) [alpha]-Cadina-4,9-diene 13.08 0.93 (iii) Cedrene
13.64 4.04 (iv) Gamma.
Cinnamaldehyde ([IC.sub.50] = 2.93 [mu]g/ml) (a representative for aldehydes), nerolidol ([IC.sub.50] = 15.78 [mu]g/ml) (an alcohol), cedrene ([IC.sub.50] = 4.07[mu]g/ml) (a hydrocarbon), benzyl isothiocyanate ([IC.sub.50] = 1.20[mu]g/ml) (a representative for mustard oils), 1.8-cineole ([IC.sub.50] = 83.15 [mu]g/ml) (an ether), safrole ([IC.sub.50]= 18.40 [mu]g/ml) (aromatics with allyl and/or methoxy side chains), carvone ([IC.sub.50] = 12.94 [mu]g/ml) (a ketone), styrene oxide ([IC.sub.50] = 3.76[mu]g/ml) (an epoxide) and carvacrol ([IC.sub.50] = 11.25 [mu]g/ml) (a phenol) showed the most potent trypanocidal activities from their respective groups.
Benzyl isothiocyanate ([IC.sub.50] = 4.62 ([mu]g/ml) was the most cytotoxic agent, followed by caryophyllene ([IC.sub.50] = 19.31[mu]g/ml) and cedrene ([IC.sub.50] = 22.20 [mu]g/ml).
The hydrocarbons (cedrene, caryophyllene and limonene) also exhibited substantial trypanocidal activities.
Germacrene B (3.1%), patchoulene (2.7%), [beta]-elemene (2.1%), cedrene
(2.0%), and isocaryophyllene (2.1%) were found in appreciable amounts in the oil.
versicolor at 2.5 mg/mL while cedrene showed only 31 and 13 percent inhibition against G.
Gas chromatography-mass spectrometry analysis identified skeletons of sesquiterpenes and sesquiterpene alcohols in both extracts and the most abundant compounds identified, cedrol, cedrenes, and thujopsenes, were individually screened for antifungal activity.