The plasmid mediated AmpC [beta]-lactamases are derived from chromosomally encoded genes and hydrolyse all [beta]-lactam antibiotics except cefepime
25 [micro]g/mL), was up to 2-fold more active than cefepime
The tested antibiotics were amikacin (AN), ciprofloxacin (CP), imipenem (IPM), gentamicin (GM), ceftazidime (CAZ), tobramycin (TOB), piperacillin-tazobactam (TZP), cefepime
(CPM), colistin (CST), and co trimoxazole (TMP/SMX).
pneumoniae also showed high resistance against Cefepime
Other antibiotics tested were: imipenem, meropenem, tazobactum, amikacin, cefoperazone sulbactam, gentamicin, cefepime
, ceftazidime, co-amoxiclav, ticarcillin, aztreonam, cefoperazone, co-trimoxazole, cefotaxime, cefixime, ceftriaxone, pipemidic acid and ampicillin.
pneumoniae Kp81 Amikacin [greater than or equal to] 64 (R) Aztreonam [greater than or equal to] 64 (R) Cefepime
[greater than or equal to] 64 (R) Ceftazidime [greater than or equal to] 64 (R) Ciprofloxacin [greater than or equal to] 4 (R) Colistin [less than or equal to] 0.
The sensitive rates to cefepime
and imipenem were 87.
EVD was replaced and the patient received cefepime
and ciprofloxacin for 21 days after which he improved and discharged with right sided residual weakness.
The isolates were tested with different antibiotics which included amikacin (30 ug), aztreonam (30 ug), cefixime (5 ug), cefotaxime (30 ug), amoxicillin-clavulanate (20/10 ug), cefpodoxime (30 ug), cefepime
(30 ug), cefoxitin (30 ug), imipenem (10 ug), meropenem (10 ug), ceftazidime (30 ug), ceftriaxone (30 ug), gentamicin (10 ug), sulbactam-cefoperazone (75/30 ug), piperacillin-tazobactam (100/10 ug), ciprofloxacin (5 ug) and cefuroxime (30 ug).
Antimicrobial sensitivity discs was done on 15 antimicrobial agents were used:--Amikacin [30ug], Cefotaxime [10ug] Cefepime
[30ug], Chloramphenicol [30ug], Ciprofloxacin [5ug], Erythromycin [15ug], Flumequine [30ug] Gentamicin [10ug], Levofloxacin [30ug], Meropenem [10ug], Ofloxacin [5ug], Piperacillin [10ug], Tobramycin [10ug], Tetracycline [30ug], and Trimethoprim sulfamethoxazole[1.
He was empirically started on vancomycin, cefepime
, and levofloxacin for sepsis of unknown origin.
The antibiotics used for AST were Ciprofloxacin, Gentamicin, Amikacin, Ceftazidime, Ceftriaxone, Ceftriaxone +Tazobactum, Sparfloxacin, Amoxicillin + Clavulanic acid, Cefepime
+ Tazobactam, Enrofloxacin, Oxacillin, Cefoxitin and Linezolid.