Cefuzime, a prescription drug available under the brand names Ceftin
and Zinacef, is an antibiotic used to treat bacterial infections, while Profinal is used to reduce body temperature and offer pain relief for inflammatory conditions and is generally prescribed to children.
* Cephalosporins: Cephalexin (Keflex, Keftabs), cefazolin (Ancef), cefaclor (Ceclor), cefuroxime (Ceftin
), cefadroxil (Duracef)
The effective medications are oral Amoxicillin, Doxycycline, Ceftin
, and intravenous Ceftriaxone.
profits from such popular drugs as Zantac, a stomach remedy, Imitrex, for treatment of migraines, and Ceftin
, an antibiotic.
in the past, it was thought that anyone with a penicillin (or amoxicillin, or ampicillin) allergy couldn't take any antibiotics from the class of "cephalosporins," like Omnicef, Ceftin
, Vantin, Keflex or many others.
In 2004, GSK sued the IRS, claiming it had erred in increasing GSK's income by $7.8 billion ($4.5 billion for cost of goods sold, $1.9 billion for royalties, and $1.4 billion for interest income) for intercompany transactions involving Zantac, Ventolin, Ceftin
, Zonfran, Imitrex, and Serevent.
Elsewhere in the regional portfolio, GlaxoSmithKline was in the spotlight after a rival pharmaceutical firm gained approval from the Food and Drug Administration to market a generic version of GSK's paediatric anti-bacterial drug Ceftin
, which is used in the treatment of mild to moderate infections.
(172) The package insert for GSK's cefuroxime axetil drug (Ceftin
) described the active ingredient as being "in the amorphous form." (173) GSK contended that "approving a drug product wholly or partially composed of the crystalline form of cefuroxime axetil would flout the requirement that the labeling of an ANDA product be the same as that of the reference listed drug." (174) The FDA rejected GSK's argument and approved the labeling changes proposed by ANDA applicants: "Consistent with this regulatory scheme, FDA may approve a generic cefuroxime axetil tablet product whose labeling states that the active ingredient is wholly or partially in crystalline form." (175)
TABLE 4 Compliance-Enhancing Ranking of Antibiotic Suspensions STRONGLY COMPLIANCE-ENHANCING * Amoxicillin * Cefdinir (Omnicef) * Loracarbef (Lorabid) * Cefaclor (Ceclor) * Cefixime (Suprax) MODERATELY COMPLIANCE-ENHANCING * Cefprozil (Cefzil) * Ceftibuten (Cedax) EQUIVOCAL COMPLIANCE-ENHANCING * Azithromycin (Zithromax) NOT COMPLIANCE-ENHANCING * Amoxicillin-clavulanate (Augmentin) * Erythromycin-sulfasoxazole (Pediazole) * TMP-SMX (Bactrim or Septra) DISCOURAGES COMPLIANCE * Cefpodoxime (Vantin) * Cefuroxime (Ceftin
) * Clarithromycin (Biaxin) TMP-SMX, trimethoprim sulfamethoxazole Sources: Adapted from Steele RW, et al.
Some of the commonly used brand names are Ceclor, Ceftin
, Kefzol, Velosef, and Omnicef (see second paragraph, previous page, for additional names).
The most commonly used drug was cefpodoxime (Vantin), in four studies, followed by cefuroxime (Ceftin
), in three studies.
While amoxicillin, trimethoprim/sulfamethoxazole (TMP/SMX) (Septra/Bactrim), erythromycin and doxycycline are still flrstline drugs for upper and lower respiratory tract infections, it is important to save Ceftin
, Vantin, Spectracef, Avelox, Levaquin and Tequin for cases involving resistant pneumococcus, Moraxella catarrhalis and Haemophilus influenzae.