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n.1.(Chem.) an antifungal antibiotic, C12H17NO3. It inhibits the growth of yeasts by interfering with the synthesis of sterols and fatty acids.
References in periodicals archive ?
Further, inhibition of FASN catalytic activity by agents such as cerulenin and C75 preferentially induce apoptosis of cancer cells (Pizer et al.
FAS inhibitor cerulenin reduces food intake and melanocortin receptor gene expression without modulating the other (an)orexigenic neuropeptides in chickens.
In the in vitro trial, T47D and MCF-7 cancer cells were cultured and then treated with canola oil and two common anti-cancer drugs: tamoxifen and cerulenin.
Fatty acid synthase inhibition with Cerulenin demonstrated a protective effect toward hepatic ischemia/reperfusion injury.
Cerulenin was the first characterized FASN inhibitor derived from the fungus Cephalosporum caerulens (Omura 1976).
Cerulenin is an antibiotic that is effective at inhibiting the passage of fatty acids from the cytoplasm to the mitochondria.