Sun, Structural modification of sanguinarine and chelerythrine
and their antibacterial activity, Nat.
Potentiation of dopamine-induced currents in B8 by GABA and baclofen was blocked by the [GABA.sub.B] antagonist phaclofen, the non-specific G-protein inhibitor GDP[beta]3S, and the protein kinase C (PKC) inhibitor chelerythrine
A second neuromodulator, chelerythrine
chloride (CC) is a protein kinase C (PKC) blocker.
Abbreviations ARM: Armepavine BBM: Berbamine BBR: Berberine CHD: Chelidonine CHE: Chelerythrine
CID: Collision-induced dissociation ISQA: Isoquinoline alkaloids JTR: Jatrorrhizine MGN: Magnoflorine MS: Mass spectrometry NMC: N-Methylcoclaurine OBB: Obaberine PLT: Palmatine STP: Stylopine TIC: Total ion current.
ochroleuca, and a great variety of alkaloids (berberine, palmatine, protopine, sarguinarine, optisine, chelerythrine
, atropine, dihydrosanguinarine, dihydro-chelerythrine, [alpha]-allacriptopine, heleritrine, queilantifoline, scouletrine, reticuline, and copsitine) were identified (Israilov et al.
Yao, "Rapid determination of protopine, allocryptopine, sanguinarine and chelerythrine
in fruits of Macleaya cordata by microwave-assisted solvent and HPLC-ESI/MS," Phytochemical Analysis, vol.
In first species secretory cells of laticifers containing alkaloids chelerythrine
and sanguinarine have fluoresced in green-yellow, while second species enriched in anthraquinones have demonstrated the emission in orange-red.
In some experiments, inhibitors of NADPH oxidase, apocynin (150 or 300 [micro]M, Sigma-Aldrich) or VAS2870 (20 [micro]M, Sigma-Aldrich), or the protein kinase C inhibitors chelerythrine
(10, 50, and 100 [micro]M, Sigma-Aldrich) or Go6983 (0.1, 1, 10 [micro]M, Sigma-Aldrich) were added to the cells 20 min before addition of the L-012 dye and stimulation with PDBu or LPS.
Niu, "Protective effect of chelerythrine
against ethanol-induced gastric ulcer in mice," Chemico-Biological Interactions, vol.
Treatment with PKC inhibitor chelerythrine
or BIM-1 abolished fibroblast growth factor-2 (FGF-2) mediated protection against DOX-induced apoptosis, suggesting that PKC activation is an important prosurvival mechanism downstream of FGF-2 .
The plant contains, as major constituents, isoquinoline alkaloids (such as sanguinarine, chelidonine, chelerythrine
, berberine, protopine and coptisine), flavonoids, and phenolic acids.
In vitro antifungal activity of sanguinarine and chelerythrine
derivatives against phytopathogenic fungi.