primary biliary cirrhosis

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primary biliary cirrhosis

n. Abbr. PBC
A chronic inflammatory disease of the liver in which the bile ducts are gradually destroyed and cirrhosis develops, thought to be an autoimmune disorder.
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Farrukh Saeed discussed treatment options for adult Cholestatic Liver Disease.
In patients diagnosed with osteoporosis who have both elevated [gamma]-glutamyltransferase and serum alkaline phosphatase levels, screening for anti-mitochondrial antibodies should be performed because of the underlying cholestatic liver disease (which may have osteoporosis as the first clinical manifestation).
The ascending pathophysiology of cholestatic liver disease.
Evidence of a systemic phenomenon for oxidative stress in cholestatic liver disease.
Idiopathic adulthood ductopenia: a cause of chronic cholestatic liver disease and biliary cirrhosis.
PBC is a rare, chronic cholestatic liver disease characterized by an immune-mediated destruction of smalland medium-sized intrahepatic bile ducts (Invernizzi, Selmi, & Gershwin, 2010).
Trauner, "Fibrosis in autoimmune and cholestatic liver disease," Best Practice and Research: Clinical Gastroenterology, vol.
Despite this knowledge, the role of hepatic cholesterol accumulation in cholestatic liver disease has not been thoroughly examined.
Background: Primary biliary cirrhosis (PBC) is a chronic and slowly progressive cholestatic liver disease characterized by destruction of the interlobular bile ducts and a striking female predominance.
EASL clinical practice guideline management of cholestatic liver disease.
2,3] These changes are particularly prominent in children with severe cholestatic liver disease such as biliary atresia and the severe intrahepatic causes of CLD.
It is the most common cause of chronic cholestatic liver disease in adults.