Its pharmaceuticals are used successfully to treat inflammatory bowel disease, cholestatic liver disease
, irritable bowel syndrome, constipation, and for colon cleansing prior to colonoscopies.
Histologic examination of the liver explant showed severe cholestatic liver disease
with intrahepatic cholestasis, focal bile cannalicular plugs, mild to moderate focal peri-portal and sinusoidal fibrosis, yielding no definitive cause for the liver disease.
Liver fibrosis represents the common response of the liver to a variety of insults, including hepatitis, toxins, viruses, alcohol abuse, metabolic diseases, autoimmune diseases, and cholestatic liver disease
Farrukh Saeed discussed treatment options for adult Cholestatic Liver Disease
. Treatment has to be for a longer period with steroids.
Patients with TJP2 deficiency display severe progressive cholestatic liver disease
in early childhood, which puts them at increased risk of developing hepatocellular carcinoma .
In patients diagnosed with osteoporosis who have both elevated [gamma]-glutamyltransferase and serum alkaline phosphatase levels, screening for anti-mitochondrial antibodies should be performed because of the underlying cholestatic liver disease
(which may have osteoporosis as the first clinical manifestation).
The ascending pathophysiology of cholestatic liver disease
. Hepatology 65,722-738.
Gershwin, "Pathogenesis of cholestatic liver disease
and therapeutic approaches," Gastroenterology, vol.
Hoskins et al., "Fibrogenesis in pediatric cholestatic liver disease
: role of taurocholate and hepatocyte-derived monocyte chemotaxis protein-1 in hepatic stellate cell recruitment," Hepatology, vol.
Primary biliary cholangitis (PBC), formerly known as primary biliary cirrhosis [5, 6], is an autoimmune cholestatic liver disease
, affecting up to 1 in 1000 women over 40 years of age with complaints such as fatigue and/or pruritus [7-9].
Chronic cholestatic liver disease
is also observed after liver transplantation .
Evidence of a systemic phenomenon for oxidative stress in cholestatic liver disease
. Gut 2000;47(5):710-6.