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A natural amine, C5H15NO2, often classed in the vitamin B complex, that is a constituent of lecithin and other phospholipids and is a precursor of certain biologically important molecules, such as acetylcholine.


(ˈkəʊliːn; -ɪn; ˈkɒl-)
(Biochemistry) a colourless viscous soluble alkaline substance present in animal tissues, esp as a constituent of lecithin: used as a supplement to the diet of poultry and in medicine for preventing the accumulation of fat in the liver. Formula:[(CH3)3NCH2CH2OH]+OH
[C19: from chole- + -ine2, so called because of its action in the liver]


(ˈkoʊ lin, ˈkɒl in)

a viscous fluid, C5H14N + O, that is a constituent of lecithin and a primary component of the neurotransmitter acetylcholine: one of the B complex vitamins.
[1865–70; < German Cholin (1862) < Greek chol(ḗ) bile + -in -ine2]
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.choline - a B-complex vitamin that is a constituent of lecithin; essential in the metabolism of fat
B complex, B vitamin, B-complex vitamin, vitamin B, vitamin B complex, B - originally thought to be a single vitamin but now separated into several B vitamins
References in periodicals archive ?
Currently, it is known that choline deficiency - usually brought about by fetal alcohol exposure --is a public health problem, and choline deficiency is the leading preventable cause of intellectual disability.
The deficient diet was previously associated to increase plasma Hcy levels in dams and to a significant methyl-group deficit in the brain fetus, caused by vitamin B and choline deficiency.
Up to 90% of us may have some level of choline deficiency because our bodies can only produce small amounts of this vitamin.
Animal model studies reveal adequate levels of choline are required for appropriate formation of phospholipid membranes and the neurotransmitter acetylcholine, with choline deficiency, producing neurological impairment (2).
Perosis caused by choline deficiency was reduced by increasing dietary choline level.
Choline deficiency can have adverse effects, including fatty liver, and liver and muscle damage.
Estrogen stimulates the endogenous synthesis of phosphatidylcholine via the phosphatidylethanolamine N-methyltransferase (PEMT) pathway, thus it is the likely explanation for the high percentage of choline deficiency in response to a low-choline diet in post-menopausal women.
In monogastric animals, choline deficiency has been shown to result in hepatic lipidosis.
Although choline deficiency does not occur in non-pregnant adult women, it is estimated that approximately 30% of women are choline deficient during pregnancy because of the extraordinary requirements for choline by the fetus.