3) Like mast cells in the lungs or skin, they release histamine, leukotrienes, thromboxane, platelet activation factor (PAF), tryptase, chymase
, and renin once activated by allergic stimuli.
Beneficial effects of astragalus polysaccharides treatment on cardiac chymase
activities and cardiomyopathy in diabetic hamsters.
Histological characterization of mast cell chymase
in patients with pulmonary hypertension and chronic obstructive pulmonary disease.
Lee, A Combination of Receptor-Based Pharmacophore Modeling and QM Techniques for Identification of Human Chymase
Contributions of mast cells and vasoactive products, leukotrienes and chymase
, to dengue virus-induced vascular leakage.
Skin lesions developed due to proliferation of mast cells and increase in chymase
and tryptase activity in body of ear sore affected buffaloes (Noviana et al.
Mutation of several genes has been implicated in the systemic "atopic" immune response, characterized by a Th2 dominance and elevated IgE levels, such as IL-4, IL-4 receptor, and IL-13, or altered cutaneous inflammation, such as mast cell chymase
Omalizumab is a humanized monoclonal antibody of IgG1 subclass which binds free IgE antibody, the main trigger of mast cell degranulation and release of histamine, leukotrienes, tryptase, chymase
, prostaglandin D2 and other cytokines involved in the pathogenesis of CSU/CIU.
84) In mice, mucosal mast cells predominantly express the chymase
mouse mast cell protease 1, which has an essential role in preventing infestation by the nematode Trichinella spiralis.
A novel (TG)n(GA)m repeat polymorphism 254 bp downstream of the mast cell chymase
(CMA1) gene is associated with atopic asthma and total serum IgE levels.
There are two main categories of mast cells, according to their type of serine protease, tryptase, a trypsin-like enzyme, and chymase
, a chymotrypsin-like enzyme, tryptase-positive mast cells (MCT), which contain tryptase but not chymase
, and the tryptase-and chymase
-positive mast cells (MCtc), which contain both enzymes [9, 10].
Many pre-formed mediators are involved in an anaphylactic reaction, including histamine, tryptase, chymase
, mast cell carboxypeptidases, platelet activating factor and others.