Medical treatment may include a broad spectrum antifungal agent such as
ciclopirox, or, in cases of infection with bacteria such as Pseudomonas, topical application of gentamicin solution.
WASHINGTON -- Combination treatment of onychomycosis using two topical treatments--40% urea gel and 8%
ciclopirox lacquer--resulted in 100% mycologic cure in a pilot study with 18 patients.
With the approval by the US Food and Drug Administration (FDA) of terbinafine in 1996 and the subsequent approval of the topical agent
ciclopirox in 1999, interest in diagnosing and treating onychomycosis increased.
Propranolol HCl $31,347,513.21 Teva USA Ursodiol $31,306,330.47 Sandoz Glyburide-Metformin HCl $31,249,271.52 Teva USA Benazepril HCl $31,127,774.18 Sandoz Hydroxychloroquine Sulfate $30,985,193.80 Sandoz Methylphenidate HCl $30,965,599.63 Ivax Pharm.t Doxycycline Hyclate $30,896,991.42 Teva USA Cefprozil $30,863,108.45 Fougera
Ciclopirox $30,822,648.27 Actavis Totowa Quinaretic $30,701,762.61 West-Ward Butalbital/Apap/Caffeine $30,653,367.44 Dr.
Patients in the Medicis-funded study followed the avoidance regimen and applied
ciclopirox 0.77% lotion twice a day for 6-12 weeks.
Maintenance therapy with topical
ciclopirox (Penlac) 2 days per week helps prevent relapse.
Ciclopirox, FDA-approved in 1999, was the first of these to be introduced.
The Food and Drug Administration has granted tentative approval to the company's Abbreviated New Drug Application (ANDA) for
ciclopirox topical solution, 8%.
The application of urea prior to
ciclopirox may improve penetration of the antifungal agent into the nail plate and thereby boost
ciclopirox's efficacy, Dr.
Drug Dosage Cost/Tube *
ciclopirox twice a day $31.83 (Loprox) clotrimazole twice a day $14.87 econazole once or $28.70 (Spectazole) twice a day ketoconazole once or $31.78 twice a day naftifine twice a day $31.73 (20 (Naftin) g); $54.40 (40 g) terbinafine twice a day $58.40 (Lamisil) SYSTEMIC AGENTS Drug Dosage Cost/Day ** terbinafine 250 mg/day $8.68 (Lamisil) itraconazole 200-400 $15.56 (200 (Sporanox) mg/day mg) Drug Comment ([dagger])
ciclopirox Pyradone, formulated as cream, gel, lotion, and topical (Loprox) suspension.
Ciclopirox, a synthetic antifungal agent, has been available in the United States since 1996.
It has been given FDA approval for
ciclopirox topical suspension.