Novartis manufactures the drugs clozapine (Clozaril), diclofenac (Voltaren), carbamazepine (Tegretol), valsartan (Diovan), imatinib mesylate (Gleevec/Glivec), ciclosporin
(Neoral/Sandimmun), letrozole (Femara), methylphenidate (Ritalin), terbinafine (Lamisil), and others.
The carcinogenicity of ciclosporin
. Toxicology 73(1):1-22, PMID: 1589877, https://doi.org/10.1016/0300-483X(92)90166-C.
Patients were excluded if they had pre-existing renal insufficiency [estimated glomerular filtration rate (eGFR) <60 mL/min/1.73], congestive heart failure, and peripheral vascular disease and if they used nephrotoxic drugs, such as aminoglycosides, amphotericin, and ciclosporin
His prior treatments included a variety of oral immunomodulators, ciclosporin
(discontinued because of severe mood changes), sulfasalazine (stopped due to erythrodermic flare), and methotrexate (both oral and subcutaneous) up to 25 mg weekly for 2 years with little benefit.
In the European Union, ustekinumab is approved for the treatment of moderate to severe plaque psoriasis in adults who failed to respond to, who have a contraindication to, or are intolerant to other systemic therapies including ciclosporin
, methotrexate or psoralen plus ultraviolet A, and is also indicated for the treatment of moderate-to-severe plaque psoriasis in adolescent patients from the age of 12 years and older who are inadequately controlled by, or are intolerant to, other systemic therapies or phototherapies.
Some of the medicines, such as aspirin, lithium, ACE inhibitors, ciclosporin
, pentoxifylline, warfarin and methotrexate, interact with ketoprofen leading to various complications.
Tapering of steroids after 03 months treatment course was associated with relapse in 03 cases and remission achieved with 100-200 mg of ciclosporin
in consolidation with 5-10 mg of deltacortil.
Several other anti-inflammatory drugs such as corticosteroids (64, 65), dapsone (66-68), and ciclosporin
(69, 70) can be employed (32) before trying biologic treatments; however, the evidence level is unsatisfactory (71).
An analysis of two phase three studies has found that the anti-inflammatory medication, ciclosporin
A, reduces symptoms of moderate to severe dry eye disease.
Are switches from oral to subcutaneous methotrexate or addition of ciclosporin
to methotrexate useful steps in a tight control treatment strategy for rheumatoid arthritis?
Therapies that are frequently utilized in patients consist of topical antipruritic, oral antihistamines, tricyclic antidepressants, topical and intra lesional steroids, narrowband UVB, psoralen-UVA therapy, cryotherapy, topical vitamin D, thalidomide, ciclosporin
and naltrexone and many others.5 Sheskin in 1973 initiated the use of thalidomide in PN.