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Any of a class of drugs that decrease insulin resistance and are used to treat type 2 diabetes.
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References in periodicals archive ?
Another study reported that PPARI3 agonist ciglitazone down regulated the NOX regulatory subunit of p47-phox oxidase in phagocytes (Von et al., 2002).
PPAR-[gamma] agonists (ciglitazone and 15-deoxy-[[DELTA]-.sup.12,14]-PG J2) as molecules could significantly increase Foxp3 expression in human iTregs [13].
Moon et al., "Ciglitazone, a peroxisome proliferator-activated receptor gamma ligand, inhibits proliferation and differentiation of Th17 cells," Biomolecules & Therapeutics, vol.
We verified that glioblastoma A172 and U87 cells express PPAR[gamma] and single treatment with ciglitazone (CG) or rosiglitazone (RS) at a concentration tested in this study did not affect protein levels of PPAR[gamma] as determined by western blotting (Figure 1(d)).
Structures in Figure 9: Ciglitazone (16) was considered to be the prototype for thiazolidinediones and has a very short L2 and a different hydrophobic tail from that of Rosiglitazone but has been withdrawn from use.
Zingarelli, "Ciglitazone ameliorates lung inflammation by mo dulating the inhibitor kappaB protein kinase/nuclear factor-kappaB pathway after hemorrhagic shock," Critical Care Medicine, vol.
Adipocyte differentiation was induced with differentiation media (RPMI-based media with an in-house differentiation cocktail containing 0.5 [micro]g/ml insulin, 400 ng/ml dexamethasone, 44 [micro]g/ml IBMX, 9 ng/ml L-thyroxine, 3 pg/ml ciglitazone, 8 pg/ml d-biotin, and 10% FBS) for 3 days, and cells were then maintained for an additional 4 days in maintenance media (RPMI-based media, supplemented with 10% FBS, 0.5 [micro]g/ml insulin, and 8 [micro]g/ml d-biotin).
Louis, MO), 200 [micro]M indomethacin (Sigma-Aldrich), 10 [micro]M insulin (Sigma-Aldrich), 0.5 [micro]M isobutylmethylxanthine (IBMX; Sigma-Aldrich), 10 [micro]M ciglitazone (Sigma-Aldrich), 2mM L-glutamine (Life Technologies, Carlsbad, CA), and 100IU penicillin and 100 [micro]g/ml streptomycin (Life Technologies).
Factors and final concentrations used were DASA at 0.1 [micro]M, ciglitazone at 0.1 [micro]M, dichloroacetate at 50 [micro]M and 500 [micro]M, 2-methoxyestradiol at 0.1 [micro]M, resveratrol at 0.5 [micro]M, chloroquine at 5 [micro]M, spermidine at 1 [micro]M, ascorbic acid at 50 [micro]g/mL, and valproic acid at 5 mg/mL.
1993) technology to detect binding of chemicals to hPPAR[gamma] in competition with fluorescent ciglitazone, or binding to human glucocorticoid receptor (hGR) in competition with [[sup.3]H]-dexamethasone.
PPAR[gamma] agonists such as troglitazone and ciglitazone also inhibit metastasis by inhibiting migration of vascular endothelial cells (9).
The effect of pioglitazone, ciglitazone and englitazone (members of insulin-sensitizing thiazolidinedione derivatives) on 3T3 cells (Szalkowski et al.