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Cilostazol (Pletal) is a phospodiesterase type III inhibitor with vasodilating, metabolic and antiplatelet properties.
Darrow says patients usually will be prescribed cilostazol (Pletal), which eases walking pain and can help PAD patients walk longer distances before pain begins.
Effect of cilostazol on treadmill walking, community-based walking ability, and health-related quality of life in patients with intermittent claudication due to peripheral arterial disease: meta-analysis of six randomized controlled trials.
Other Medications cilostazol (Pletal)-- * Grapefruit significan- * Avoid grapefruit, treats circulatory tly increases blood grapefruit juice and conditions levels of the drug, Seville oranges.
Casi Pharmaceuticals announced a strategic and long-term manufacturing agreement with Yiling Wanzhou International Pharmaceutical for the manufacturing of entecavir and cilostazol. Yiling Wanzhou International Pharmaceutical is a subsidiary of Shijiazhuang Yiling Pharmaceutical.
In a regression analysis adjusted for possible confounding factors such as lipid levels and hemoglobin A1c, theimprovements in common carotid artery intima-media thickness with cilostazol treatment over aspirin treatment remained significant.
Single-dose pharmacokinetics of cilostazol, voriconazole, or raltegravir in healthy volunteers were not significantly altered following pretreatment of Ginkgo biloba extracts 80 mg twice daily for 7 days, 120 mg twice daily for 12 days, or 120 mg twice daily for 15 days, respectively [77-79].
Interestingly, another antiplatelet drug, cilostazol, with a completely different mechanism of action that reduces platelet reactivity and degranulation, also reduced A[beta]-induced cognitive deficits associated with A[beta] accumulation [47-50], while aspirin, which reduces platelet aggregation but has no effect on degranulation, has no effect .
Coronary stent restenosis in patients treated with cilostazol. Circulation 2005;112:2826-32.
Symptoms may be controlled with medications such as cilostazol (Pletal) and lifestyle changes.
Kano et al., "Cilostazol inhibits oxidative stress-induced premature senescence via upregulation of Sirt1 in human endothelial cells," Arteriosclerosis, Thrombosis, and Vascular Biology, vol.
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