2-Mercaptoethanol (BME), zinc chloride (Zn[Cl.sub.2]), clioquinol
(CQ), calcium disodium ethylene diamine tetraacetate (CaEDTA), Triton X-100, dimethylsulfoxide (DMSO), butylated hydroxyanisole (BHA), anti-mouse IgG-HRP, and anti-rabbit IgG-HRP were purchased from Sigma (MO, USA).
 The etiologies of myelopathy were MS, heredodegenerative, systemic lupus erythematosus, electrocution, spinal cord infarction, and clioquinol
. In 23 (28.0%) patient's etiology could not be established.
Moreover, a 1-week treatment with the zinc chelator, clioquinol
, decreased zinc staining in the hippocampus and reduced the number of progenitor cells.
Another compound named 5-chloro-7-iodo-quinolin8-ol (clioquinol
), which is recognized as iron chelator that blocks the generation of [H.sub.2][O.sub.2], induced toxicity by A[beta]; thus it shows neuroprotective effect .
Iron is a reactant in the formation of the hydroxyl radical, a highly reactive ROS, via the Fenton reaction, and iron chelating agents, such as clioquinol
(CQ) and deferoxamine, reduced ICH-induced brain edema, neuronal death, and brain atrophy in a rat ICH model [49-51].
reported that the antiparasitic clioquinol
is a HDAC inhibitor that induces expression of p53, leading to apoptosis in leukemia and myeloma cells .
Yan, "Tumor cellular proteasome inhibition and growth suppression by 8-hydroxyquinoline and clioquinol
requires their capabilities to bind copper and transport copper into cells" Journal of Biological Inorganic Chemistry, vol.
For example, clioquinol
had good activity in guinea pigs but not in mice (Lewis et al., 1970, Tison., 1952).
and docosahexaenoic acid act synergistically to kill tumor cells.