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1. One of two or more contributing factors.
2. A substance, such as a metallic ion or coenzyme, that must be associated with an enzyme for the enzyme to function.


1. (Mathematics) maths a number associated with an element in a square matrix, equal to the determinant of the matrix formed by removing the row and column in which the element appears from the given determinant. See minor
2. (Biochemistry) biochem a nonprotein substance that forms a complex with certain enzymes and is essential for their activity. It may be a metal ion or a coenzyme


(ˈkoʊˌfæk tər)

1. a contributing factor.
2. any of various organic or inorganic substances necessary to the function of an enzyme.
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.cofactor - a substance (as a coenzyme) that must join with another to produce a given result
chemical compound, compound - (chemistry) a substance formed by chemical union of two or more elements or ingredients in definite proportion by weight
References in periodicals archive ?
Manganese is used by the body as a co-factor for the antioxidant enzyme, superoxide dismutase.
A key co-factor for the enzymes that metabolize tryptophan into serotonin and melatonin is vitamin B6.
Natural ingredients include a host of antioxidants and co-factor nutrients that aid in collagen production and marine fish collagen which our body needs to combat oxidative stress and cellular repair.
In contrast, they found that vitamin C boosted the activity of the TET enzymes by regenerating a co-factor required for effective action.
Zinc is a co-factor in many enzymes which regulate growth, development and digestion.
Editor's Note: As possible cancer-protective mechanisms for vitamin B6, the authors cite its role as a co-factor for enzymes involved in DNA synthesis and methylation pathways of one-carbon metabolism, as well as an ability to protect DNA from oxidative damage.
NAD+ is the most important cellular co-factor for improvement of mitochondrial performance and energy.
Manganese is a co-factor for the enzyme superoxide dismutase, which is a very powerful free radical scavenger.
The current paradigm of how NO production is regulated focuses at the level of nitric oxide synthase (NOS), with respect to substrate and co-factor availability and the precise spatial and temporal arrangement of protein complexes.
NAD+ is arguably the most important cellular co-factor for improvement of mitochondrial performance and energy.
4 Alcohol abuse has been identified as a co-factor.